Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OXTR | P30559 | 5/20 | 0.69 |
| ▸ | AVPR1A | P37288 | 3/20 | 0.58 |
| ▸ | CAPN1 | P07384 | 2/20 | 0.38 |
| ▸ | MMP1 | P03956 | 1/20 | 0.37 |
| ▸ | MMP3 | P08254 | 1/20 | 0.37 |
| ▸ | MMP7 | P09237 | 1/20 | 0.37 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | CTSB | P07858 | 1/20 | 0.37 |
| ▸ | CTSS | P25774 | 1/20 | 0.37 |
| ▸ | CTSK | P43235 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | HTR1A | P08908 | 1/20 | 0.36 |
| ▸ | HTR1B | P28222 | 1/20 | 0.36 |
| ▸ | HTR2A | P28223 | 1/20 | 0.36 |
| ▸ | HTR2C | P28335 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4942152 | 0.86 | OXTR (0.69) | OXTRAVPR1AMMP1MMP3MMP7 | |
| SCHEMBL4944228 | 0.85 | OXTR (0.73) | OXTRAVPR1AMMP1MMP3MMP7 | |
| SCHEMBL6094401 | 0.83 | OXTR (0.46) | OXTRAVPR1ACAPN1MCL1POLB | |
| SCHEMBL6094412 | 0.83 | OXTR (0.46) | OXTRAVPR1ACAPN1MCL1POLB | |
| SCHEMBL5742342 | 0.83 | OXTR (0.71) | OXTRAVPR1AMMP1MMP3MMP7 | |
| SCHEMBL4944113 | 0.83 | OXTR (0.71) | OXTRAVPR1AMMP1MMP3MMP7 | |
| SCHEMBL5041532 | 0.82 | OXTR (0.68) | OXTRAVPR1AMMP1MMP3MMP7 | |
| SCHEMBL5482133 | 0.82 | OXTR (0.68) | OXTRAVPR1AMMP1MMP3MMP7 | |
| SCHEMBL4936262 | 0.81 | OXTR (1.00) | OXTRAVPR1AMMP1MMP3MMP7 | |
| SCHEMBL4945256 | 0.81 | OXTR (1.00) | OXTRAVPR1AMMP1MMP3MMP7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1268419-A1 | PYRROLIDINE DERIVATIVES USEFUL AS BAX INHIBITORS | Applied Research Systems ARS Holding N.V. (AN) | 2003-01-02 | — | — | EP | disclosed |
| WO-2001072705-A1 | PHARMACEUTICALLY ACTIVE PYRROLIDINE DERIVATIVES AS BAX INHIBITORS | APPLIED RESEARCH SYSTEMS ARS HOLDING N.V. (AN) | 2001-10-04 | — | — | WO | disclosed |