Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 8/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.52 |
| ▸ | HPGD | P15428 | 2/20 | 0.52 |
| ▸ | RAB9A | P51151 | 5/20 | 0.51 |
| ▸ | LMNA | P02545 | 5/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.51 |
| ▸ | RECQL | P46063 | 2/20 | 0.51 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.51 |
| ▸ | NPC1 | O15118 | 3/20 | 0.49 |
| ▸ | POLB | P06746 | 3/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.49 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 2/20 | 0.48 |
| ▸ | CYP17A1 | P05093 | 2/20 | 0.47 |
| ▸ | NAMPT | P43490 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7084616 | 1.00 | MAPT (0.52) | MAPTALDH1A1HPGDRAB9ALMNA | |
| SCHEMBL5819746 | 0.81 | L3MBTL1 (0.58) | MAPTALDH1A1HPGDRAB9ALMNA | |
| SCHEMBL5819742 | 0.81 | L3MBTL1 (0.58) | MAPTALDH1A1HPGDRAB9ALMNA | |
| SCHEMBL9106572 | 0.81 | MAPT (0.47) | MAPTALDH1A1HPGDRAB9ALMNA | |
| SCHEMBL9106575 | 0.81 | MAPT (0.47) | MAPTALDH1A1HPGDRAB9ALMNA | |
| SCHEMBL6819065 | 0.80 | HDAC3 (0.41) | MAPTALDH1A1HPGDRAB9ACYP1A2 | |
| SCHEMBL6819063 | 0.80 | HDAC3 (0.41) | MAPTALDH1A1HPGDRAB9ACYP1A2 | |
| SCHEMBL6071499 | 0.79 | RAB9A (0.60) | MAPTALDH1A1HPGDRAB9ALMNA | |
| SCHEMBL5821517 | 0.79 | RAB9A (0.60) | MAPTALDH1A1HPGDRAB9ALMNA | |
| SCHEMBL13055402 | 0.78 | CYP17A1 (0.59) | ALDH1A1SMN1; SMN2CYP17A1NAMPTGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0862560-B1 | SUBSTITUTED 2-ANILINOPYRIMIDINES USEFUL AS PROTEIN KINASE INHIBITORS | CELLTECH THERAPEUTICS LTD (GB) | 2003-04-02 | — | — | EP | disclosed |
| US-6235746-B1 | AUTOIMMUNE DISEASES; ANTIPROLIFERATIVE AGENT | CELLTECH THERAPEUTICS, LIMITED (GB) | 2001-05-22 | — | — | US | disclosed |
| US-5958935-A | Substituted 2-anilinopyrimidines useful as protein kinase inhibitors | CELLTECH THERAPEUTICS LIMITED (GB) | 1999-09-28 | — | — | US | disclosed |