Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDPK1 | O15530 | 1/20 | 0.43 |
| ▸ | BRAF | P15056 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | TLK2 | Q86UE8 | 2/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | GRM5 | P41594 | 3/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | IDO1 | P14902 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | STK10 | O94804 | 3/20 | 0.39 |
| ▸ | SLK | Q9H2G2 | 3/20 | 0.39 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.38 |
| ▸ | KDR | P35968 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7084876 | 1.00 | PDPK1 (0.43) | PDPK1BRAFALDH1A1MAPTTLK2 | |
| SCHEMBL7088689 | 0.90 | KDR (0.44) | PDPK1ALDH1A1MAPTTLK2MEN1 | |
| SCHEMBL7088684 | 0.90 | KDR (0.44) | PDPK1ALDH1A1MAPTTLK2MEN1 | |
| SCHEMBL6320241 | 0.88 | ALDH1A1 (0.46) | BRAFALDH1A1MAPTTLK2HTT | |
| SCHEMBL6322601 | 0.88 | ALDH1A1 (0.46) | BRAFALDH1A1MAPTTLK2HTT | |
| SCHEMBL7087980 | 0.88 | PDPK1 (0.50) | PDPK1ALDH1A1MAPTTLK2LMNA | |
| SCHEMBL7087977 | 0.88 | PDPK1 (0.50) | PDPK1ALDH1A1MAPTTLK2LMNA | |
| SCHEMBL7086761 | 0.87 | PDPK1 (0.45) | PDPK1TLK2KDR | |
| SCHEMBL29643001 | 0.87 | PDPK1 (0.45) | PDPK1TLK2KDR | |
| SCHEMBL7086762 | 0.87 | PDPK1 (0.45) | PDPK1TLK2KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1071665-B1 | SUBSTITUTED INDOLINONES HAVING AN INHIBITING EFFECT ON KINASES AND CYCLINE/CDK COMPLEXES | BOEHRINGER INGELHEIM PHARMA (DE) | 2003-10-01 | — | — | EP | disclosed |
| EP-1071665-A1 | SUBSTITUTED INDOLINONES HAVING AN INHIBITING EFFECT ON KINASES AND CYCLINE/CDK COMPLEXES | Boehringer Ingelheim Pharma KG (DE) | 2001-01-31 | — | — | EP | disclosed |
| WO-1999052869-A1 | SUBSTITUTED INDOLINONES HAVING AN INHIBITING EFFECT ON KINASES AND CYCLINE/CDK COMPLEXES | BOEHRINGER INGELHEIM PHARMA KG (DE) | 1999-10-21 | — | — | WO | disclosed |