Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 2/20 | 0.44 |
| ▸ | PDPK1 | O15530 | 3/20 | 0.42 |
| ▸ | PAK4 | O96013 | 1/20 | 0.39 |
| ▸ | TLK2 | Q86UE8 | 3/20 | 0.38 |
| ▸ | F2 | P00734 | 1/20 | 0.37 |
| ▸ | PLG | P00747 | 1/20 | 0.37 |
| ▸ | PLAU | P00749 | 1/20 | 0.37 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.37 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.37 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.37 |
| ▸ | EGFR | P00533 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | PGR | P06401 | 1/20 | 0.36 |
| ▸ | AKT1 | P31749 | 1/20 | 0.36 |
| ▸ | AKT2 | P31751 | 1/20 | 0.36 |
| ▸ | BRD4 | O60885 | 1/20 | 0.36 |
| ▸ | BRD2 | P25440 | 1/20 | 0.36 |
| ▸ | GSK3B | P49841 | 3/20 | 0.35 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7088689 | 1.00 | KDR (0.44) | KDRPDPK1PAK4TLK2F2 | |
| SCHEMBL7082903 | 0.90 | PDPK1 (0.47) | PDPK1TLK2MAPTAKT1AKT2 | |
| SCHEMBL7082906 | 0.90 | PDPK1 (0.47) | PDPK1TLK2MAPTAKT1AKT2 | |
| SCHEMBL7084876 | 0.90 | PDPK1 (0.43) | KDRPDPK1TLK2MAPTMEN1 | |
| SCHEMBL7084871 | 0.90 | PDPK1 (0.43) | KDRPDPK1TLK2MAPTMEN1 | |
| SCHEMBL7086761 | 0.89 | PDPK1 (0.45) | KDRPDPK1TLK2AKT1AKT2 | |
| SCHEMBL29643001 | 0.89 | PDPK1 (0.45) | KDRPDPK1TLK2AKT1AKT2 | |
| SCHEMBL7086762 | 0.89 | PDPK1 (0.45) | KDRPDPK1TLK2AKT1AKT2 | |
| SCHEMBL7492390 | 0.88 | KDR (0.43) | KDRPDPK1PAK4TLK2F2 | |
| SCHEMBL7082441 | 0.87 | PDPK1 (0.45) | PDPK1TLK2MAPTAKT1AKT2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1071665-B1 | SUBSTITUTED INDOLINONES HAVING AN INHIBITING EFFECT ON KINASES AND CYCLINE/CDK COMPLEXES | BOEHRINGER INGELHEIM PHARMA (DE) | 2003-10-01 | — | — | EP | disclosed |
| EP-1071665-A1 | SUBSTITUTED INDOLINONES HAVING AN INHIBITING EFFECT ON KINASES AND CYCLINE/CDK COMPLEXES | Boehringer Ingelheim Pharma KG (DE) | 2001-01-31 | — | — | EP | disclosed |
| WO-1999052869-A1 | SUBSTITUTED INDOLINONES HAVING AN INHIBITING EFFECT ON KINASES AND CYCLINE/CDK COMPLEXES | BOEHRINGER INGELHEIM PHARMA KG (DE) | 1999-10-21 | — | — | WO | disclosed |