Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRA | P10827 | 11/20 | 0.53 |
| ▸ | THRB | P10828 | 11/20 | 0.53 |
| ▸ | HTR2A | P28223 | 3/20 | 0.52 |
| ▸ | HTR2C | P28335 | 3/20 | 0.52 |
| ▸ | HTR2B | P41595 | 3/20 | 0.52 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.43 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.43 |
| ▸ | HTR1A | P08908 | 1/20 | 0.38 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6512292 | 0.88 | THRA (0.59) | THRATHRBHTR2AHTR2CHTR2B | |
| SCHEMBL7089038 | 0.84 | THRA (0.58) | THRATHRBHTR2AHTR2CHTR2B | |
| SCHEMBL7090946 | 0.83 | THRA (0.51) | THRATHRBHTR2AHTR2CHTR2B | |
| SCHEMBL6514286 | 0.82 | THRA (0.62) | THRATHRBHTR2AHTR2CHTR2B | |
| SCHEMBL6514122 | 0.82 | THRA (0.59) | THRATHRBHTR2AHTR2CHTR2B | |
| SCHEMBL6985722 | 0.81 | THRA (0.56) | THRATHRBHTR2AHTR2CHTR2B | |
| SCHEMBL7082348 | 0.81 | THRA (0.55) | THRATHRBHTR2AHTR2CHTR2B | |
| SCHEMBL6515707 | 0.80 | THRB (0.60) | THRATHRBHTR2AHTR2CHTR2B | |
| SCHEMBL7082734 | 0.80 | THRA (0.70) | THRATHRBMTNR1AMTNR1B | |
| SCHEMBL6984598 | 0.80 | HTR2C (0.53) | THRATHRBHTR2AHTR2CHTR2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1268422-A1 | INDOLES FOR TREATING DISEASES THAT CAN BE TREATED USING THYROID HORMONES | Bayer Aktiengesellschaft (DE) | 2003-01-02 | — | — | EP | disclosed |
| WO-2001070687-A1 | INDOLES FOR TREATING DISEASES THAT CAN BE TREATED USING THYROID HORMONES | BAYER AKTIENGESELLSCHAFT (DE) | 2001-09-27 | — | — | WO | disclosed |