Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA1D | P25100 | 20/20 | 0.48 |
| ▸ | ADRA1A | P35348 | 20/20 | 0.48 |
| ▸ | ADRA1B | P35368 | 20/20 | 0.48 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.42 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.42 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.42 |
| ▸ | HRH1 | P35367 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7077852 | 0.92 | ADRA1D (0.56) | ADRA1DADRA1AADRA1B | |
| SCHEMBL7079636 | 0.92 | ADRA1D (0.47) | ADRA1DADRA1AADRA1B | |
| Hydrochloric Acid SCHEMBL7083488 | 0.91 | ADRA1D (0.55) | ADRA1DADRA1AADRA1B | |
| SCHEMBL7168450 | 0.87 | ADRA1A (0.60) | ADRA1DADRA1AADRA1B | |
| SCHEMBL7084620 | 0.86 | ADRA1D (0.60) | ADRA1DADRA1AADRA1B | |
| SCHEMBL7084124 | 0.84 | ADRA1D (0.54) | ADRA1DADRA1AADRA1B | |
| SCHEMBL7078221 | 0.84 | ADRA1D (0.46) | ADRA1DADRA1AADRA1B | |
| SCHEMBL7080849 | 0.83 | ADRA1A (0.64) | ADRA1DADRA1AADRA1B | |
| Hydrochloric Acid SCHEMBL7080847 | 0.83 | ADRA1D (0.64) | ADRA1DADRA1AADRA1B | |
| SCHEMBL7164513 | 0.82 | ADRA1D (0.57) | ADRA1DADRA1AADRA1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0998285-A4 | ALPHA 1a ADRENERGIC RECEPTOR ANTAGONISTS | MERCK & CO INC (US) | 2003-01-08 | — | — | EP | claimed |
| EP-0998285-A1 | ALPHA 1a ADRENERGIC RECEPTOR ANTAGONISTS | Merck & Co., Inc. (US) | 2000-05-10 | — | — | EP | claimed |
| WO-1998057641-A1 | ALPHA 1a ADRENERGIC RECEPTOR ANTAGONISTS | MERCK & CO., INC. (US) | 1998-12-23 | — | — | WO | claimed |