Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 14/20 | 0.34 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.32 |
| ▸ | HSD11B2 | P80365 | 2/20 | 0.32 |
| ▸ | SCN1A | P35498 | 1/20 | 0.31 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.31 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1118091 | 0.89 | HSD11B1 (0.35) | HSD11B1SCN9AHSD11B2 | |
| SCHEMBL1116549 | 0.83 | HSD11B1 (0.41) | HSD11B1 | |
| SCHEMBL705603 | 0.82 | HSD11B1 (0.42) | HSD11B1 | |
| SCHEMBL705598 | 0.82 | HSD11B1 (0.42) | HSD11B1 | |
| SCHEMBL705599 | 0.82 | HSD11B1 (0.42) | HSD11B1 | |
| SCHEMBL1116565 | 0.79 | HSD11B1 (0.51) | HSD11B1HSD11B2 | |
| SCHEMBL1118199 | 0.78 | HSD11B1 (0.41) | HSD11B1HSD11B2 | |
| SCHEMBL705638 | 0.77 | HSD11B1 (0.37) | HSD11B1SCN9A | |
| SCHEMBL1116636 | 0.76 | HSD11B1 (0.38) | HSD11B1HSD11B2 | |
| SCHEMBL1116561 | 0.76 | HSD11B1 (0.38) | HSD11B1HSD11B2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2280970-A1 | IMIDAZOLIDINONE DERIVATIVES AS 11B-HSD1 INHIBITORS | F. Hoffmann-La Roche AG (CH) | 2011-02-09 | — | — | EP | claimed |
| WO-2009132986-A1 | IMIDAZOLIDINONE DERIVATIVES AS 11B-HSD1 INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2009-11-05 | — | — | WO | claimed |
| EP-2280970-B1 | IMIDAZOLIDINONE DERIVATIVES AS 11B-HSD1 INHIBITORS | HOFFMANN LA ROCHE (CH) | 2014-01-08 | — | — | EP | disclosed |
| US-8124636-B2 | Imidazolidinone derivatives as 11B-HSD1 inhibitors | HOFFMANN-LA ROCHE INC. (US) | 2012-02-28 | — | — | US | disclosed |
| EP-2280970-A1 | IMIDAZOLIDINONE DERIVATIVES AS 11B-HSD1 INHIBITORS | F. Hoffmann-La Roche AG (CH) | 2011-02-09 | — | — | EP | disclosed |
| WO-2009132986-A1 | IMIDAZOLIDINONE DERIVATIVES AS 11B-HSD1 INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2009-11-05 | — | — | WO | disclosed |