Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.54 |
| ▸ | GAA | P10253 | 2/20 | 0.54 |
| ▸ | MAPT | P10636 | 4/20 | 0.51 |
| ▸ | NPC1 | O15118 | 1/20 | 0.51 |
| ▸ | ACACB | O00763 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 3/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | BLM | P54132 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | MCHR1 | Q99705 | 2/20 | 0.45 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.45 |
| ▸ | HTR2A | P28223 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | F10 | P00742 | 2/20 | 0.43 |
| ▸ | SAE1 | Q9UBE0 | 1/20 | 0.42 |
| ▸ | UBA2 | Q9UBT2 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7088328 | 0.86 | MAPT (0.68) | ALDH1A1SMN1; SMN2GAAMAPTNPC1 | |
| SCHEMBL7091303 | 0.83 | MAPT (0.66) | ALDH1A1SMN1; SMN2GAAMAPTNPC1 | |
| SCHEMBL4586702 | 0.79 | ALDH1A1 (0.51) | ALDH1A1SMN1; SMN2ACACBPOLBKMT2A | |
| SCHEMBL5164898 | 0.79 | SMN1; SMN2 (0.52) | ALDH1A1SMN1; SMN2GAAMAPTNPC1 | |
| SCHEMBL5443184 | 0.78 | MAPT (0.57) | ALDH1A1SMN1; SMN2MAPTLMNATSHR | |
| SCHEMBL5164072 | 0.77 | NPC1 (0.51) | ALDH1A1SMN1; SMN2MAPTNPC1KMT2A | |
| SCHEMBL17507085 | 0.77 | SMN1; SMN2 (0.55) | ALDH1A1SMN1; SMN2GAAMAPTNPC1 | |
| SCHEMBL7150779 | 0.76 | HTT (0.63) | ALDH1A1SMN1; SMN2MAPTNPC1POLB | |
| SCHEMBL17541774 | 0.76 | GAA (0.50) | ALDH1A1SMN1; SMN2GAAMAPTNPC1 | |
| SCHEMBL17507082 | 0.76 | GAA (0.50) | ALDH1A1SMN1; SMN2GAAMAPTNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1341755-A1 | CARBOXYLIC ACID AMIDE DERIVATIVES AND THEIR USE IN THE TREATMENT OF THROMBOEMBOLIC DISEASES AND TUMOURS | MERCK PATENT GmbH (DE) | 2003-09-10 | — | — | EP | disclosed |
| WO-2002048099-A1 | CARBOXYLIC ACID AMIDE DERIVATIVES AND THEIR USE IN THE TREATMENT OF THROMBOEMBOLIC DISEASES AND TUMOURS | MERCK PATENT GMBH (DE) | 2002-06-20 | — | — | WO | disclosed |