Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | CXCR4 | P61073 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | ALDH2 | P05091 | 1/20 | 0.40 |
| ▸ | FNTA | P49354 | 4/20 | 0.40 |
| ▸ | FNTB | P49356 | 4/20 | 0.40 |
| ▸ | PGGT1B | P53609 | 4/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | GLA | P06280 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | PDE5A | O76074 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7081202 | 0.82 | POLB (0.47) | POLBMEN1KMT2AFNTAFNTB | |
| SCHEMBL7082948 | 0.81 | CYP11B1 (0.54) | FNTAFNTBPGGT1B | |
| SCHEMBL7082546 | 0.79 | FNTA (0.44) | POLBMEN1KMT2AFNTAFNTB | |
| Hydrochloric Acid SCHEMBL6602509 | 0.73 | FNTA (0.49) | POLBMEN1KMT2AFNTAFNTB | |
| SCHEMBL6968640 | 0.73 | CYP1A2 (0.50) | CXCR4MEN1KMT2ACYP3A4CYP1A2 | |
| SCHEMBL6599662 | 0.72 | CYP11B1 (0.52) | POLBMEN1KMT2AFNTAFNTB | |
| SCHEMBL27580269 | 0.69 | TSHR (0.62) | MEN1KMT2AFNTAFNTBPGGT1B | |
| SCHEMBL8493862 | 0.67 | FNTA (0.49) | FNTAFNTBPGGT1B | |
| SCHEMBL7078584 | 0.66 | CYP11B1 (0.53) | FNTAFNTBPGGT1B | |
| SCHEMBL6598797 | 0.66 | FNTA (0.48) | MEN1KMT2AFNTAFNTBPGGT1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1200430-A4 | THIOUREA AND ISOTHIOUREA DERIVATIVES FOR INHIBITING RAS-TRANSFORMED CELL GROWTH | YUHAN CORP LTD (KR) | 2003-01-22 | — | — | EP | disclosed |
| EP-1200430-A1 | THIOUREA AND ISOTHIOUREA DERIVATIVES FOR INHIBITING RAS-TRANSFORMED CELL GROWTH | YUHAN CORPORATION, LTD. (KR) | 2002-05-02 | — | — | EP | disclosed |
| WO-2001009128-A1 | THIOUREA AND ISOTHIOUREA DERIVATIVES FOR INHIBITING RAS-TRANSFORMED CELL GROWTH | YUHAN CORPORATION (KR) | 2001-02-08 | — | — | WO | disclosed |