Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | USP1 | O94782 | 2/20 | 0.40 |
| ▸ | WDR48 | Q8TAF3 | 2/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | FNTA | P49354 | 3/20 | 0.39 |
| ▸ | FNTB | P49356 | 3/20 | 0.39 |
| ▸ | PGGT1B | P53609 | 3/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | HTR5A | P47898 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7086424 | 0.82 | POLB (0.45) | POLBMEN1KMT2AFNTAFNTB | |
| SCHEMBL7082328 | 0.79 | ALDH1A1 (0.45) | ALDH1A1MEN1KMT2ASMN1; SMN2KDM4E | |
| SCHEMBL27580313 | 0.78 | ALDH1A1 (0.43) | ALDH1A1L3MBTL1MEN1KMT2AHTT | |
| SCHEMBL27559617 | 0.75 | ALDH1A1 (0.40) | ALDH1A1L3MBTL1KMT2AUSP1WDR48 | |
| SCHEMBL7081814 | 0.73 | SCN8A (0.44) | POLBALDH1A1MEN1KMT2AHTT | |
| SCHEMBL7083126 | 0.73 | LMNA (0.44) | POLBALDH1A1L3MBTL1MEN1KMT2A | |
| SCHEMBL6599662 | 0.72 | CYP11B1 (0.52) | POLBL3MBTL1MEN1KMT2AKDM4E | |
| SCHEMBL7078383 | 0.71 | FNTA (0.53) | FNTAFNTBPGGT1B | |
| SCHEMBL27580269 | 0.71 | TSHR (0.62) | ALDH1A1L3MBTL1MEN1KMT2ASMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL6602509 | 0.71 | FNTA (0.49) | POLBL3MBTL1MEN1KMT2AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1200430-A4 | THIOUREA AND ISOTHIOUREA DERIVATIVES FOR INHIBITING RAS-TRANSFORMED CELL GROWTH | YUHAN CORP LTD (KR) | 2003-01-22 | — | — | EP | disclosed |
| CN-1376155-A | Thiourea and isothiourea derivatives for inhibiting RAS-transformed cell growth | YUHAN CORP (KR) | 2002-10-23 | — | — | CN | disclosed |
| EP-1200430-A1 | THIOUREA AND ISOTHIOUREA DERIVATIVES FOR INHIBITING RAS-TRANSFORMED CELL GROWTH | YUHAN CORPORATION, LTD. (KR) | 2002-05-02 | — | — | EP | disclosed |
| WO-2001009128-A1 | THIOUREA AND ISOTHIOUREA DERIVATIVES FOR INHIBITING RAS-TRANSFORMED CELL GROWTH | YUHAN CORPORATION (KR) | 2001-02-08 | — | — | WO | disclosed |