Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | HRH3 | Q9Y5N1 | 7/20 | 0.42 |
| ▸ | HRH2 | P25021 | 5/20 | 0.41 |
| ▸ | HRH1 | P35367 | 5/20 | 0.41 |
| ▸ | LTA4H | P09960 | 2/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5217780 | 0.86 | KDM4E (0.59) | L3MBTL1KDM4EMEN1KMT2AHRH3 | |
| SCHEMBL5216362 | 0.77 | KDM4E (0.54) | L3MBTL1KDM4EMEN1KMT2AHRH3 | |
| SCHEMBL5218206 | 0.76 | HRH2 (0.54) | L3MBTL1KDM4EHRH3HRH2HRH1 | |
| SCHEMBL5216009 | 0.74 | HRH2 (0.54) | KDM4EMEN1KMT2AHRH3HRH2 | |
| SCHEMBL5214617 | 0.73 | HRH2 (0.67) | L3MBTL1KDM4EHRH3HRH2HRH1 | |
| SCHEMBL5215408 | 0.73 | HRH2 (0.69) | KDM4EHRH3HRH2HRH1 | |
| SCHEMBL5221219 | 0.71 | KDM4E (0.47) | KDM4EHRH3HRH2HRH1 | |
| SCHEMBL5216544 | 0.71 | KDM4E (0.51) | KDM4EHRH3HRH2HRH1 | |
| SCHEMBL5215403 | 0.70 | HRH3 (0.64) | HRH3HRH2HRH1 | |
| SCHEMBL1751111 | 0.69 | L3MBTL1 (0.57) | L3MBTL1KDM4EMEN1KMT2AHRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1301480-A1 | 1,3-DISUBSTITUTED AND 1,3,3-TRISUBSTITUTED PYRROLIDINES AS HISTAMINE-3 RECEPTOR LIGANDS AND THEIR THERAPEUTIC APPLICATIONS | ABBOTT LABORATORIES (US) | 2003-04-16 | — | — | EP | disclosed |
| WO-2002006223-A1 | 1,3-DISUBSTITUTED AND 1,3,3-TRISUBSTITUTED PYRROLIDINES AS HISTAMINE-3 RECEPTOR LIGANDS AND THEIR THERAPEUTIC APPLICATIONS | ABBOTT LABORATORIES (US) | 2002-01-24 | — | — | WO | disclosed |