Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.48 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.48 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.48 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.48 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.48 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.48 |
| ▸ | APP | P05067 | 2/20 | 0.42 |
| ▸ | IDO1 | P14902 | 2/20 | 0.41 |
| ▸ | TP53 | P04637 | 3/20 | 0.41 |
| ▸ | GAA | P10253 | 3/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | BLM | P54132 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | BCHE | P06276 | 3/20 | 0.39 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL95381 | 0.86 | TSHR (0.44) | LMNACYP1A2PTGS1SLC6A2CYP2C19 | |
| SCHEMBL3973667 | 0.84 | IDO1 (0.48) | LMNAPTGS1APPIDO1GAA | |
| SCHEMBL6796911 | 0.84 | MAOB (0.44) | LMNAMAPTKMT2AALDH1A1TDP1 | |
| SCHEMBL5790467 | 0.84 | TP53 (0.40) | LMNACYP1A2APPTP53MAPT | |
| SCHEMBL2451731 | 0.84 | MAOB (0.43) | LMNAPTGS1SLC6A2PTGS2SLC6A3 | |
| SCHEMBL1907545 | 0.84 | MAOB (0.43) | LMNACYP1A2PTGS1CYP2C19PTGS2 | |
| SCHEMBL7383564 | 0.82 | NR4A2 (0.57) | HPGDPOLBSMN1; SMN2 | |
| SCHEMBL2451926 | 0.81 | APP (0.49) | APPIDO1MEN1KMT2ABCHE | |
| SCHEMBL8719864 | 0.80 | MAOB (0.56) | LMNAKMT2AALDH1A1L3MBTL1SMN1; SMN2 | |
| SCHEMBL7284886 | 0.80 | HSD17B10 (0.44) | LMNAALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1996009823-A9 | HYPOGLYCEMIC AGENT FROM CRYPTOLEPIS | — | 1996-05-23 | — | — | WO | claimed |
| WO-1996009823-A1 | HYPOGLYCEMIC AGENT FROM CRYPTOLEPIS | SHAMAN PHARMACEUTICALS, INC. (US) | 1996-04-04 | — | — | WO | claimed |
| WO-2003068736-A2 | MIXED STEROIDAL 1,2,4,5-TETRAOXANE COMPOUNDS AND METHODS OF MAKING AND USING THEREOF | U.S. ARMY MEDICAL RESEARCH AND MATERIAL COMMAND (US) | 2003-08-21 | — | — | WO | disclosed |