Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ELANE | P08246 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | TUBB4A | P04350 | 5/20 | 0.35 |
| ▸ | TUBB | P07437 | 5/20 | 0.35 |
| ▸ | TUBA3C | P0DPH7 | 5/20 | 0.35 |
| ▸ | TUBA1B | P68363 | 5/20 | 0.35 |
| ▸ | TUBA4A | P68366 | 5/20 | 0.35 |
| ▸ | TUBB4B | P68371 | 5/20 | 0.35 |
| ▸ | TUBB3 | Q13509 | 5/20 | 0.35 |
| ▸ | TUBB2A | Q13885 | 5/20 | 0.35 |
| ▸ | TUBB8 | Q3ZCM7 | 5/20 | 0.35 |
| ▸ | TUBA3E | Q6PEY2 | 5/20 | 0.35 |
| ▸ | TUBA1A | Q71U36 | 5/20 | 0.35 |
| ▸ | TUBA1C | Q9BQE3 | 5/20 | 0.35 |
| ▸ | TUBB6 | Q9BUF5 | 5/20 | 0.35 |
| ▸ | TUBB2B | Q9BVA1 | 5/20 | 0.35 |
| ▸ | TUBB1 | Q9H4B7 | 5/20 | 0.35 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4920355 | 0.72 | HSD17B10 (0.40) | ELANEKDM4ETDP1HSD17B10MAPK1 | |
| SCHEMBL4930253 | 0.65 | HSD17B10 (0.41) | ELANEKDM4ETDP1HSD17B10MAPK1 | |
| SCHEMBL1735826 | 0.61 | ADORA2A (0.59) | KDM4ETDP1HSD17B10PTPN1KMT2A | |
| SCHEMBL15231432 | 0.61 | KDM4E (0.49) | ELANEKDM4ETDP1HSD17B10PTPN1 | |
| SCHEMBL7335145 | 0.61 | TNKS (0.56) | KDM4ETDP1HSD17B10MAPK1KMT2A | |
| SCHEMBL8545080 | 0.60 | ALDH1A1 (0.54) | KDM4ETDP1HSD17B10MAPK1KMT2A | |
| SCHEMBL20600721 | 0.59 | ADORA2A (0.71) | KDM4ETDP1HSD17B10MAPK1KMT2A | |
| SCHEMBL28926315 | 0.58 | HPGD (0.42) | KDM4ETDP1HSD17B10MAPK1KMT2A | |
| SCHEMBL1419899 | 0.58 | KDM4E (0.50) | KDM4ETDP1HSD17B10MAPTALDH1A1 | |
| SCHEMBL30309814 | 0.58 | KDM4E (0.65) | KDM4ETDP1HSD17B10PTPN1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1326613-A1 | USE OF SUBSTITUTED IMIDAZO 1,2-A]PYRIDINE-, IMIDAZO 1,2-A]PYRIMIDINE AND IMIDAZO 1,2-A]PYRAZINE-3-YL-AMINE DERIVATIVES FOR PRODUCING NOS-INHIBITING MEDICAMENTS | Grünenthal GmbH (DE) | 2003-07-16 | — | — | EP | claimed |
| WO-2002030428-A1 | USE OF SUBSTITUTED IMIDAZO[1,2-A]PYRIDINE-, IMIDAZO[1,2-A]PYRIMIDINE AND IMIDAZO[1,2-A]PYRAZINE-3-YL-AMINE DERIVATIVES FOR PRODUCING NOS-INHIBITING MEDICAMENTS | Grünenthal GmbH (DE) | 2002-04-18 | — | — | WO | claimed |