Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 4/20 | 0.59 |
| ▸ | DNMT1 | P26358 | 1/20 | 0.49 |
| ▸ | EGLN1 | Q9GZT9 | 2/20 | 0.39 |
| ▸ | ABL1 | P00519 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | POLB | P06746 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | ALDH1A3 | P47895 | 2/20 | 0.37 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15418868 | 0.83 | ADORA2A (0.52) | ADORA2ADNMT1ALDH1A1KDM4EPOLB | |
| SCHEMBL1733176 | 0.80 | ADORA2A (0.63) | ADORA2ADNMT1EGLN1ABL1KDM4E | |
| SCHEMBL1733339 | 0.78 | ALDH1A3 (0.38) | EGLN1ALDH1A1ALDH1A3NR4A2ALDH1A2 | |
| SCHEMBL1733833 | 0.77 | ALDH1A1 (0.41) | EGLN1ALDH1A1KDM4EPOLBMEN1 | |
| SCHEMBL1728540 | 0.76 | ADORA2A (0.58) | ADORA2ADNMT1EGLN1ALDH1A1KDM4E | |
| SCHEMBL15418924 | 0.74 | ALDH1A1 (0.37) | EGLN1ALDH1A1KDM4EPOLBMEN1 | |
| SCHEMBL1733971 | 0.74 | NR4A2 (0.59) | EGLN1ALDH1A1ALDH1A3NR4A2ALDH1A2 | |
| SCHEMBL3773742 | 0.74 | ADORA2A (0.55) | ADORA2ADNMT1ALDH1A1KDM4EPOLB | |
| SCHEMBL3766980 | 0.73 | CYP2C9 (0.64) | ADORA2ADNMT1EGLN1ALDH1A1KDM4E | |
| SCHEMBL1733303 | 0.73 | ALDH1A1 (0.38) | EGLN1ALDH1A1KDM4EPOLBMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2225243-B1 | Derivatives of N-heterocyclic-6-heterocyclic-imidazo[1,2-a]pyridine-2-carboxamides, preparation thereof and therapeutic application thereof | SANOFI SA (FR) | 2011-11-16 | — | — | EP | claimed |