Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.39 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.39 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | TBXAS1 | P24557 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | GDA | Q9Y2T3 | 1/20 | 0.31 |
| ▸ | FDPS | P14324 | 2/20 | 0.31 |
| ▸ | PARP1 | P09874 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1303712 | 0.80 | CSNK1A1 (0.37) | CSNK1A1TYRO3DYRK1BALDH1A1KDM4E | |
| SCHEMBL6692287 | 0.80 | CSNK1A1 (0.34) | CSNK1A1TYRO3DYRK1BALDH1A1KDM4E | |
| SCHEMBL28470761 | 0.77 | CSNK1A1 (0.35) | CSNK1A1TYRO3DYRK1BALDH1A1KDM4E | |
| SCHEMBL16448086 | 0.76 | TAAR1 (0.35) | CSNK1A1TYRO3DYRK1BALDH1A1KDM4E | |
| SCHEMBL10858073 | 0.75 | KDM4E (0.31) | CSNK1A1TYRO3DYRK1BALDH1A1KDM4E | |
| SCHEMBL27467097 | 0.73 | CSNK1A1 (0.42) | CSNK1A1TYRO3DYRK1BALDH1A1KDM4E | |
| SCHEMBL31169778 | 0.72 | ALDH1A1 (0.39) | CSNK1A1TYRO3DYRK1BALDH1A1KDM4E | |
| SCHEMBL29053330 | 0.72 | CSNK1A1 (0.41) | CSNK1A1TYRO3DYRK1BALDH1A1KDM4E | |
| SCHEMBL28717458 | 0.71 | KLK1 (0.34) | CSNK1A1TYRO3DYRK1BALDH1A1SMN1; SMN2 | |
| SCHEMBL9440949 | 0.69 | ALDH1A1 (0.37) | ALDH1A1KDM4ENPC1RAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1328272-A1 | NF-KAPPA-B INHIBITORS | SmithKline Beecham Corporation (US) | 2003-07-23 | — | — | EP | disclosed |
| WO-2002030423-A1 | NF-λB INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2002-04-18 | — | — | WO | disclosed |