SCHEMBL7086918

SCHEMBL7086918

C=C(C(N)=O)c1ccc2nc(Nc3ccccc3)ncc2n1

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SYK P43405 4/20 0.46
AURKA O14965 3/20 0.46
JAK2 O60674 2/20 0.46
AURKB Q96GD4 2/20 0.46
GSK3B P49841 5/20 0.43
GSK3A P49840 3/20 0.43
MAP4K4 O95819 2/20 0.42
IRAK4 Q9NWZ3 2/20 0.42
CDC7 O00311 2/20 0.42
ROCK2 O75116 1/20 0.42
PIM1 P11309 1/20 0.42
PRKACA P17612 1/20 0.42
CDK7 P50613 1/20 0.42
CDK9 P50750 1/20 0.42
HIPK2 Q9H2X6 1/20 0.42
MAPK8 P45983 4/20 0.42
IGF1R P08069 2/20 0.42
MAPK9 P45984 2/20 0.42
PLK4 O00444 1/20 0.42
PDPK1 O15530 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7086914 0.74 CYP1A2 (0.43) SYKAURKAJAK2AURKBGSK3B
SCHEMBL1262022 0.74 MKNK2 (0.54) AURKBMAP4K4PIM1PRKACAMAPK8
SCHEMBL7086916 0.74 CYP1A2 (0.43) SYKAURKAJAK2AURKBGSK3B
SCHEMBL12120895 0.71 JAK2 (0.51) SYKAURKAJAK2AURKBGSK3B
SCHEMBL20609242 0.69 MGAM (0.59) MEN1CYP1A2CYP2C9TSHRKMT2A
SCHEMBL4047005 0.68 CDK2 (0.50) SYKAURKAJAK2AURKBGSK3B
SCHEMBL4487993 0.66 HDAC6 (0.68) SYKAURKAJAK2AURKBGSK3B
SCHEMBL29466293 0.65 MAPK8 (0.60) SYKAURKAJAK2AURKBGSK3B
SCHEMBL167891 0.65 MAP3K5 (0.60) SYKAURKAJAK2AURKBGSK3B
SCHEMBL31381352 0.65 MAP3K5 (0.60) SYKAURKAJAK2AURKBGSK3B

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1366027-A1 COMBI-MOLECULES HAVING SIGNAL TRANSDUCTION INHIBITORY PROPERTIES AND DNA DAMAGING PROPERTIES McGILL UNIVERSITY (CA) 2003-12-03 EP disclosed
WO-2002068396-A1 COMBI-MOLECULES HAVING SIGNAL TRANSDUCTION INHIBITORY PROPERTIES AND DNA DAMAGING PROPERTIES MCGILL UNIVERSITY (CA) 2002-09-06 WO disclosed