Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 1/20 | 0.41 |
| ▸ | MAOB | P27338 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.38 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.38 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.38 |
| ▸ | MMP13 | P45452 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 4/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.37 |
| ▸ | PPARA | Q07869 | 3/20 | 0.37 |
| ▸ | MAPT | P10636 | 3/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7087030 | 0.71 | PPARA (0.40) | MAOAMAOBCYP3A4SMN1; SMN2HDAC6 | |
| SCHEMBL2003706 | 0.69 | PPARA (0.44) | MMP13MEN1KMT2APPARAMAPT | |
| SCHEMBL1996467 | 0.67 | LOXL2 (0.50) | MAOAMAOBCYP3A4SMN1; SMN2HDAC6 | |
| SCHEMBL11205218 | 0.64 | SMN1; SMN2 (0.51) | SMN1; SMN2HDAC6PTGS1PTGS2KMT2A | |
| SCHEMBL8122840 | 0.64 | SENP7 (0.57) | SMN1; SMN2HDAC6MEN1KMT2AMAPT | |
| SCHEMBL1172020 | 0.64 | CYP3A4 (0.70) | CYP3A4SMN1; SMN2MEN1KMT2ALMNA | |
| SCHEMBL2001919 | 0.63 | LOXL2 (0.51) | MAOAMAOBSMN1; SMN2HDAC6MMP13 | |
| SCHEMBL3711953 | 0.63 | SMN1; SMN2 (0.53) | CYP3A4SMN1; SMN2HDAC6MEN1KMT2A | |
| SCHEMBL2595772 | 0.62 | SMN1; SMN2 (0.56) | CYP3A4SMN1; SMN2HDAC6PTGS1PTGS2 | |
| Nitromide SCHEMBL193674 | 0.61 | CYP3A4 (1.00) | CYP3A4SMN1; SMN2MEN1KMT2ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1296967-A1 | QUINOLINYL AND BENZOTHIAZOLYL PPAR-GAMMA MODULATORS | Tularik Inc. (US) | 2003-04-02 | — | — | EP | disclosed |
| WO-2002000633-A1 | QUINOLINYL AND BENZOTHIAZOLYL PPAR-GAMMA MODULATORS | TULARIK INC. (US) | 2002-01-03 | — | — | WO | disclosed |