Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX1 | P07099 | 4/20 | 0.35 |
| ▸ | ESRRG | P62508 | 4/20 | 0.34 |
| ▸ | ACACB | O00763 | 4/20 | 0.33 |
| ▸ | ESRRB | O95718 | 2/20 | 0.33 |
| ▸ | ACE | P12821 | 1/20 | 0.33 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | COPS5 | Q92905 | 1/20 | 0.32 |
| ▸ | PDE2A | O00408 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6753529 | 0.83 | ESRRG (0.34) | ESRRGACACBESRRBCOPS5PDE2A | |
| SCHEMBL6747644 | 0.83 | CTSL (0.42) | ESRRGESRRB | |
| SCHEMBL6295788 | 0.81 | EPHX1 (0.33) | EPHX1ESRRGACACBESRRBSCN9A | |
| SCHEMBL6972743 | 0.78 | EPHX1 (0.36) | EPHX1ESRRGACACBESRRBACE | |
| SCHEMBL6749636 | 0.77 | SLC7A5 (0.42) | — | |
| SCHEMBL6989542 | 0.74 | TP53 (0.40) | ESRRGESRRB | |
| SCHEMBL6749679 | 0.74 | CTSL (0.42) | — | |
| SCHEMBL6295858 | 0.74 | EPHX1 (0.33) | EPHX1ACACBSCN9AKMT2A | |
| SCHEMBL6751806 | 0.74 | CTSL (0.54) | ACE | |
| SCHEMBL6751639 | 0.73 | CTSL (0.50) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1362042-A1 | CYCLIC 2-CARBONYLAMINOKETONES AS INHIBITORS OF CRUZIPAIN AND OTHER CYSTEINE PROTEASES | Amura Therapeutics Limited (GB) | 2003-11-19 | — | — | EP | disclosed |
| WO-2002057249-A1 | CYCLIC 2-CARBONYLAMINOKETONES AS INHIBITORS OF CRUZIPAIN AND OTHER CYSTEINE PROTEASES | AMURA THERAPEUTICS LIMITED (GB) | 2002-07-25 | — | — | WO | disclosed |