Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX1 | P07099 | 4/20 | 0.36 |
| ▸ | ESRRG | P62508 | 5/20 | 0.35 |
| ▸ | ESRRB | O95718 | 2/20 | 0.34 |
| ▸ | CTSK | P43235 | 2/20 | 0.33 |
| ▸ | NAAA | Q02083 | 1/20 | 0.33 |
| ▸ | ACACB | O00763 | 2/20 | 0.32 |
| ▸ | COPS5 | Q92905 | 1/20 | 0.32 |
| ▸ | ACE | P12821 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5870406 | 0.87 | NAAA (0.41) | CTSKNAAAACE | |
| SCHEMBL5870571 | 0.82 | ALDH1A1 (0.36) | ESRRGESRRBCTSKNAAAACACB | |
| SCHEMBL5870448 | 0.82 | NAAA (0.37) | ESRRGESRRBCTSKNAAAACACB | |
| SCHEMBL6962186 | 0.80 | OPRD1 (0.37) | MAPT | |
| SCHEMBL7087280 | 0.78 | EPHX1 (0.35) | EPHX1ESRRGESRRBACACBCOPS5 | |
| SCHEMBL5870401 | 0.76 | PSMB5 (0.40) | CTSKNAAAALDH1A1MAPT | |
| SCHEMBL6803808 | 0.74 | CTSK (0.55) | EPHX1ESRRGCTSKACE | |
| SCHEMBL5870460 | 0.74 | ME2 (0.36) | CTSKACE | |
| SCHEMBL6295788 | 0.73 | EPHX1 (0.33) | EPHX1ESRRGESRRBACACBALDH1A1 | |
| SCHEMBL5870248 | 0.71 | PSMB5 (0.43) | CTSKNAAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1358174-A2 | INHIBITORS OF CRUZIPAIN AND OTHER CYSTEINE PROTEASES | Amura Therapeutics Limited (GB) | 2003-11-05 | — | — | EP | disclosed |
| WO-2002057248-A2 | INHIBITORS OF CRUZIPAIN AND OTHER CYSTEINE PROTEASES | AMURA THERAPEUTICS LIMITED (GB) | 2002-07-25 | — | — | WO | disclosed |