Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CAPN1 | P07384 | 1/20 | 0.53 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 3/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | TP53 | P04637 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.40 |
| ▸ | BLM | P54132 | 1/20 | 0.40 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Iodide SCHEMBL6796588 | 0.99 | CAPN1 (0.52) | CAPN1HSD11B1POLBMAPTTP53 | |
| SCHEMBL7175203 | 0.89 | MAPT (0.48) | CAPN1HSD11B1POLBMAPTTP53 | |
| Iodide SCHEMBL6790320 | 0.89 | MAPT (0.48) | CAPN1HSD11B1POLBMAPTTP53 | |
| Iodide SCHEMBL6795037 | 0.88 | CAPN1 (0.41) | CAPN1LMNATHRB | |
| SCHEMBL7090390 | 0.87 | CAPN1 (0.47) | CAPN1HSD11B1POLBMAPTTP53 | |
| Iodide SCHEMBL6796460 | 0.87 | CAPN1 (0.41) | CAPN1HSD11B1POLBMAPTTP53 | |
| Iodide SCHEMBL6797798 | 0.86 | CAPN1 (0.46) | CAPN1HSD11B1POLBMAPTTP53 | |
| Iodide SCHEMBL6792333 | 0.86 | PTGS1 (0.53) | HSD11B1LMNAKDM4EPTGS1USP2 | |
| SCHEMBL6793771 | 0.85 | CAPN1 (0.53) | CAPN1HSD11B1POLBMAPTTP53 | |
| SCHEMBL7090095 | 0.83 | MAPT (0.42) | CAPN1HSD11B1POLBMAPTTP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1343774-A1 | 1,1-DIOXO-2H-1, 2-BENZOTHIAZINE-3-CARBOXAMIDE DERIVATIVES, METHOD FOR PREPARING SAME AND PHARMACEUTICAL COMPOSITIONS COMPRISING SAME | Les Laboratoires Servier (FR) | 2003-09-17 | — | — | EP | disclosed |
| WO-2002050049-A1 | 1,1-DIOXO-2H-1, 2-BENZOTHIAZINE-3-CARBOXAMIDE DERIVATIVES, METHOD FOR PREPARING SAME AND PHARMACEUTICAL COMPOSITIONS COMPRISING SAME | LES LABORATOIRES SERVIER (FR) | 2002-06-27 | — | — | WO | disclosed |