Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.42 |
| ▸ | POLB | P06746 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | RECQL | P46063 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.39 |
| ▸ | CAPN1 | P07384 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | THPO | P40225 | 1/20 | 0.37 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 3/20 | 0.37 |
| ▸ | HTR2B | P41595 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Iodide SCHEMBL6794705 | 0.99 | MAPT (0.41) | MAPTPOLBALDH1A1CYP3A4CYP2C9 | |
| Iodide SCHEMBL6796460 | 0.87 | CAPN1 (0.41) | MAPTPOLBCYP3A4CYP2C9SMN1; SMN2 | |
| SCHEMBL7087940 | 0.83 | CAPN1 (0.53) | MAPTPOLBCYP3A4CYP2C9SMN1; SMN2 | |
| Iodide SCHEMBL6796588 | 0.83 | CAPN1 (0.52) | MAPTPOLBCYP3A4CYP2C9CYP2C19 | |
| SCHEMBL7175203 | 0.82 | MAPT (0.48) | MAPTPOLBSMN1; SMN2HSD11B1CAPN1 | |
| Iodide SCHEMBL6790320 | 0.81 | MAPT (0.48) | MAPTPOLBSMN1; SMN2HSD11B1CAPN1 | |
| SCHEMBL6796572 | 0.80 | MAPT (0.52) | MAPTPOLBALDH1A1CYP3A4CYP2C9 | |
| SCHEMBL7090390 | 0.79 | CAPN1 (0.47) | MAPTPOLBCYP3A4CYP2C9CYP2C19 | |
| Iodide SCHEMBL6797798 | 0.79 | CAPN1 (0.46) | MAPTPOLBCYP3A4CYP2C9CYP2C19 | |
| Iodide SCHEMBL6792333 | 0.78 | PTGS1 (0.53) | CYP3A4CYP2C9CYP2C19HSD11B1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1343774-A1 | 1,1-DIOXO-2H-1, 2-BENZOTHIAZINE-3-CARBOXAMIDE DERIVATIVES, METHOD FOR PREPARING SAME AND PHARMACEUTICAL COMPOSITIONS COMPRISING SAME | Les Laboratoires Servier (FR) | 2003-09-17 | — | — | EP | disclosed |
| WO-2002050049-A1 | 1,1-DIOXO-2H-1, 2-BENZOTHIAZINE-3-CARBOXAMIDE DERIVATIVES, METHOD FOR PREPARING SAME AND PHARMACEUTICAL COMPOSITIONS COMPRISING SAME | LES LABORATOIRES SERVIER (FR) | 2002-06-27 | — | — | WO | disclosed |