Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 10/20 | 0.48 |
| ▸ | TP53 | P04637 | 5/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.48 |
| ▸ | POLB | P06746 | 4/20 | 0.48 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.43 |
| ▸ | CAPN1 | P07384 | 1/20 | 0.43 |
| ▸ | HTR1A | P08908 | 1/20 | 0.42 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Iodide SCHEMBL6790320 | 0.99 | MAPT (0.48) | MAPTTP53SMN1; SMN2POLBHSD11B1 | |
| SCHEMBL7087940 | 0.89 | CAPN1 (0.53) | MAPTTP53SMN1; SMN2POLBHSD11B1 | |
| Iodide SCHEMBL6796588 | 0.88 | CAPN1 (0.52) | MAPTTP53POLBHSD11B1CAPN1 | |
| Iodide SCHEMBL6796460 | 0.85 | CAPN1 (0.41) | MAPTTP53SMN1; SMN2POLBHSD11B1 | |
| SCHEMBL7090390 | 0.85 | CAPN1 (0.47) | MAPTTP53POLBHSD11B1CAPN1 | |
| Iodide SCHEMBL6797798 | 0.84 | CAPN1 (0.46) | MAPTTP53POLBHSD11B1CAPN1 | |
| Iodide SCHEMBL6792333 | 0.84 | PTGS1 (0.53) | HSD11B1PTGS1 | |
| SCHEMBL7090095 | 0.82 | MAPT (0.42) | MAPTTP53SMN1; SMN2POLBHSD11B1 | |
| Iodide SCHEMBL6794705 | 0.81 | MAPT (0.41) | MAPTTP53SMN1; SMN2POLBHSD11B1 | |
| Iodide SCHEMBL6802074 | 0.81 | PTGS1 (0.54) | HSD11B1PTGS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1343774-A1 | 1,1-DIOXO-2H-1, 2-BENZOTHIAZINE-3-CARBOXAMIDE DERIVATIVES, METHOD FOR PREPARING SAME AND PHARMACEUTICAL COMPOSITIONS COMPRISING SAME | Les Laboratoires Servier (FR) | 2003-09-17 | — | — | EP | disclosed |
| WO-2002050049-A1 | 1,1-DIOXO-2H-1, 2-BENZOTHIAZINE-3-CARBOXAMIDE DERIVATIVES, METHOD FOR PREPARING SAME AND PHARMACEUTICAL COMPOSITIONS COMPRISING SAME | LES LABORATOIRES SERVIER (FR) | 2002-06-27 | — | — | WO | disclosed |