Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 7/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | GAA | P10253 | 4/20 | 0.43 |
| ▸ | POLB | P06746 | 3/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | RECQL | P46063 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | IGF1R | P08069 | 1/20 | 0.41 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 5/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7084013 | 0.82 | ALDH1A1 (0.48) | EGFRMAPTALDH1A1SMN1; SMN2KDM4E | |
| SCHEMBL5371868 | 0.82 | EGFR (0.41) | EGFRMAPTALDH1A1SMN1; SMN2KDM4E | |
| SCHEMBL7083252 | 0.81 | EGFR (0.46) | EGFRMAPTALDH1A1SMN1; SMN2KDM4E | |
| SCHEMBL7084060 | 0.81 | ALDH1A1 (0.44) | EGFRMAPTALDH1A1SMN1; SMN2KDM4E | |
| SCHEMBL6976057 | 0.80 | MAPT (0.45) | EGFRMAPTALDH1A1SMN1; SMN2KDM4E | |
| SCHEMBL6980038 | 0.79 | ALDH1A1 (0.45) | EGFRMAPTALDH1A1SMN1; SMN2KDM4E | |
| SCHEMBL7088181 | 0.79 | GAA (0.48) | MAPTALDH1A1SMN1; SMN2KDM4EKMT2A | |
| SCHEMBL7090424 | 0.78 | ALDH1A1 (0.49) | EGFRMAPTALDH1A1SMN1; SMN2KDM4E | |
| SCHEMBL7087949 | 0.78 | EGFR (0.48) | EGFRMAPTALDH1A1SMN1; SMN2KDM4E | |
| SCHEMBL7083578 | 0.74 | NPC1 (0.38) | MAPTSMN1; SMN2KMT2ARAB9AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1223932-A4 | COMPOUNDS AND METHODS | SMITHKLINE BEECHAM CORP (US) | 2003-01-15 | — | — | EP | disclosed |
| EP-1223932-A1 | COMPOUNDS AND METHODS | SmithKline Beecham Corporation (US) | 2002-07-24 | — | — | EP | disclosed |
| WO-2001024796-A1 | 1,2,4-TRIAZOLE DERIVATIVES, COMPOSITION, PROCESS OF MAKING AND METHODS OF USE | SMITHKLINE BEECHAM CORPORATION (US) | 2001-04-12 | — | — | WO | disclosed |