Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.48 |
| ▸ | MAPT | P10636 | 7/20 | 0.48 |
| ▸ | RAB9A | P51151 | 6/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | USP2 | O75604 | 1/20 | 0.48 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.48 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.48 |
| ▸ | RELA | Q04206 | 1/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 4/20 | 0.46 |
| ▸ | NPC1 | O15118 | 4/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | EGFR | P00533 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7080341 | 0.86 | MAPT (0.52) | ALDH1A1MAPTRAB9AKMT2AMEN1 | |
| SCHEMBL6976057 | 0.83 | MAPT (0.45) | ALDH1A1MAPTRAB9ASMN1; SMN2KMT2A | |
| SCHEMBL6980038 | 0.82 | ALDH1A1 (0.45) | ALDH1A1MAPTRAB9ASMN1; SMN2KMT2A | |
| SCHEMBL7088057 | 0.82 | EGFR (0.44) | ALDH1A1MAPTRAB9ASMN1; SMN2KMT2A | |
| SCHEMBL5376455 | 0.82 | METAP2 (0.46) | ALDH1A1MAPTRAB9ASMN1; SMN2KMT2A | |
| SCHEMBL7090424 | 0.81 | ALDH1A1 (0.49) | ALDH1A1MAPTRAB9ASMN1; SMN2KMT2A | |
| SCHEMBL7084060 | 0.81 | ALDH1A1 (0.44) | ALDH1A1MAPTRAB9ASMN1; SMN2KMT2A | |
| SCHEMBL7083896 | 0.81 | METAP2 (0.43) | ALDH1A1MAPTKMT2AMEN1ALOX15 | |
| SCHEMBL6615397 | 0.81 | METAP2 (0.49) | ALDH1A1KMT2AMEN1NPC1EGFR | |
| SCHEMBL7085264 | 0.80 | ADRA2A (0.44) | ALDH1A1MAPTRAB9AKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1223932-A4 | COMPOUNDS AND METHODS | SMITHKLINE BEECHAM CORP (US) | 2003-01-15 | — | — | EP | disclosed |
| EP-1223932-A1 | COMPOUNDS AND METHODS | SmithKline Beecham Corporation (US) | 2002-07-24 | — | — | EP | disclosed |
| WO-2001024796-A1 | 1,2,4-TRIAZOLE DERIVATIVES, COMPOSITION, PROCESS OF MAKING AND METHODS OF USE | SMITHKLINE BEECHAM CORPORATION (US) | 2001-04-12 | — | — | WO | disclosed |