Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR7 | Q9NYK1 | 3/20 | 0.50 |
| ▸ | PNP | P00491 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.44 |
| ▸ | HPGD | P15428 | 3/20 | 0.44 |
| ▸ | HTT | P42858 | 3/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | TRAP1 | Q12931 | 2/20 | 0.43 |
| ▸ | HSP90B1 | P14625 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | PDE9A | O76083 | 2/20 | 0.42 |
| ▸ | PDE5A | O76074 | 1/20 | 0.42 |
| ▸ | PDE1A | P54750 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7090943 | 0.89 | TLR7 (0.48) | TLR7KDM4EHPGDHTTLMNA | |
| SCHEMBL7676540 | 0.88 | BRD4 (0.51) | TLR7PNPHPGDGAAMEN1 | |
| SCHEMBL7090838 | 0.83 | TLR7 (0.50) | TLR7PNPKDM4EHPGDHTT | |
| SCHEMBL6674800 | 0.78 | PNP (0.54) | PNPHTTMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL7680197 | 0.77 | TLR7 (0.48) | TLR7HPGDHTTLMNAMEN1 | |
| SCHEMBL7426524 | 0.76 | KMT2A (0.43) | HPGDLMNAMEN1TSHRKMT2A | |
| SCHEMBL11017605 | 0.75 | ADORA2A (0.51) | HPGDPOLBADORA2AADORA2BADORA1 | |
| SCHEMBL7092998 | 0.72 | PDE4B (0.60) | — | |
| SCHEMBL5226057 | 0.72 | ADORA2A (0.56) | HPGDADORA2AADORA2BADORA1 | |
| SCHEMBL7088426 | 0.72 | TLR7 (0.48) | TLR7TRAP1HSP90B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0814809-B1 | ARYL THIOXANTHINES | EURO CELTIQUE SA (LU) | 2003-08-13 | — | — | EP | disclosed |
| US-6440979-B1 | Aryl isoguanines | EURO-CELTIQUE, S.A. (LU) | 2002-08-27 | — | — | US | disclosed |
| US-6090816-A | ANTIASTHMA AGENTS | EURO-CELTIQUE S.A. (LU) | 2000-07-18 | — | — | US | disclosed |
| US-6066641-A | PHOSPHODIESTERASES AS MOLECULAR TARGETS FOR ANTI-ASTHMATIC AGENTS | EURO-CELTIQUE S.A. (LU) | 2000-05-23 | — | — | US | disclosed |
| WO-1996018399-A1 | ARYL THIOXANTHINES | EURO-CELTIQUE, S.A. (LU) | 1996-06-20 | — | — | WO | disclosed |