Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 6/20 | 0.56 |
| ▸ | ADORA2B | P29275 | 6/20 | 0.56 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.56 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.54 |
| ▸ | HPGD | P15428 | 1/20 | 0.54 |
| ▸ | PDE4A | P27815 | 1/20 | 0.54 |
| ▸ | BLM | P54132 | 1/20 | 0.54 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.54 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.54 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.54 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11017605 | 0.88 | ADORA2A (0.51) | ADORA2AADORA2BADORA1ADORA3HPGD | |
| SCHEMBL7423540 | 0.86 | ADORA2A (0.45) | ADORA2AADORA2B | |
| SCHEMBL7277196 | 0.82 | ADORA2A (0.71) | ADORA2AADORA2BADORA1ADORA3HPGD | |
| SCHEMBL11015546 | 0.80 | ADORA2A (0.54) | ADORA2AADORA2BADORA1ADORA3HPGD | |
| SCHEMBL7425894 | 0.79 | ADORA2A (0.53) | ADORA2AADORA2B | |
| SCHEMBL4623457 | 0.79 | ADORA2A (0.59) | ADORA2AADORA2BADORA1ADORA3HPGD | |
| SCHEMBL3180528 | 0.79 | ADORA2A (0.59) | ADORA2AADORA2BADORA1ADORA3HPGD | |
| SCHEMBL2958488 | 0.78 | ADORA2A (0.58) | ADORA2AADORA2BADORA1ADORA3HPGD | |
| SCHEMBL7426524 | 0.77 | KMT2A (0.43) | ADORA2AADORA2BHPGDHSD17B10 | |
| SCHEMBL11019581 | 0.77 | ADORA2A (0.56) | ADORA2AADORA2BADORA1ADORA3HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1092435-B1 | REMEDIES FOR DIABETES | KYOWA HAKKO KOGYO KK (JP) | 2007-04-04 | — | — | EP | disclosed |
| US-6489331-B1 | A CONDENSED PURINE DERIVATIVE AS AN ACTIVE INGREDIENT AS AN ENHANCER OF INSULIN SECRETION AND A MEDICAMENT FOR THE TREATMENT OF DIABETES | KYOWA HAKKO KOGYO CO., LTD. (JP) | 2002-12-03 | — | — | US | disclosed |
| EP-1092435-A1 | REMEDIES FOR DIABETES | KYOWA HAKKO KOGYO CO., LTD. (JP) | 2001-04-18 | — | — | EP | disclosed |
| US-4546182-A | TREATMENT OF RESPIRATORY AND CARDIO-VASCULAR DISORDERS | AKTIEBOLAGET DRACO (SE) | 1985-10-08 | — | — | US | disclosed |