Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PSEN1 | P49768 | 13/20 | 0.36 |
| ▸ | PSEN2 | P49810 | 13/20 | 0.36 |
| ▸ | APH1B | Q8WW43 | 13/20 | 0.36 |
| ▸ | NCSTN | Q92542 | 13/20 | 0.36 |
| ▸ | APH1A | Q96BI3 | 13/20 | 0.36 |
| ▸ | PSENEN | Q9NZ42 | 13/20 | 0.36 |
| ▸ | PLAU | P00749 | 1/20 | 0.33 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7687506 | 0.84 | IDO1 (0.38) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL2343768 | 0.77 | IDO1 (0.46) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL7686972 | 0.76 | IDO1 (0.35) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL7085244 | 0.71 | PLAU (0.50) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL29949831 | 0.68 | PLAU (0.44) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL14760073 | 0.68 | PLAU (0.44) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL14990041 | 0.68 | PLAU (0.44) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL22309128 | 0.67 | IDO1 (0.39) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL5693079 | 0.66 | PLAU (0.60) | PLAU | |
| SCHEMBL7853724 | 0.66 | CHRM2 (0.42) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1010694-B1 | Spiroimidazoline derivatives and their use as alpha2-adrenergic antagonists and monoamines-reuptake blockers | SERVIER LAB (FR) | 2003-08-06 | — | — | EP | disclosed |
| US-6172097-B1 | Spiro imidazoline compounds | ADIR ET COMPAGNIE (FR) | 2001-01-09 | — | — | US | disclosed |
| EP-1010694-A2 | Spiroimidazoline derivatives and their use as alpha2-adrenergic antagonists and monoamines-reuptake blockers | ADIR ET COMPAGNIE (FR) | 2000-06-21 | — | — | EP | disclosed |