Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SERPINE1 | P05121 | 15/20 | 0.61 |
| ▸ | TSHR | P16473 | 4/20 | 0.46 |
| ▸ | LMNA | P02545 | 3/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | HTT | P42858 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7087880 | 0.88 | SERPINE1 (0.57) | SERPINE1TSHRTP53 | |
| SCHEMBL7088122 | 0.81 | SERPINE1 (0.59) | SERPINE1TSHRLMNASMN1; SMN2USP2 | |
| SCHEMBL7088384 | 0.79 | SERPINE1 (0.56) | SERPINE1TSHRLMNAMAPTSMN1; SMN2 | |
| SCHEMBL7089125 | 0.76 | SERPINE1 (1.00) | SERPINE1 | |
| SCHEMBL7089626 | 0.73 | SERPINE1 (0.51) | SERPINE1LMNAMAPTHTTSMN1; SMN2 | |
| SCHEMBL7084544 | 0.73 | SERPINE1 (0.59) | SERPINE1POLB | |
| SCHEMBL7087929 | 0.71 | SERPINE1 (0.67) | SERPINE1LMNAMAPTHTTMEN1 | |
| SCHEMBL7089111 | 0.71 | SERPINE1 (0.72) | SERPINE1TSHRLMNAMAPTHTT | |
| SCHEMBL7084183 | 0.70 | SERPINE1 (1.00) | SERPINE1TSHRLMNAHTT | |
| SCHEMBL7091877 | 0.68 | SERPINE1 (0.62) | SERPINE1TSHRLMNAMAPTHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2003080060-A1 | SUBSTITUTED PIPERAZINE ANTITHROMBOTIC PAI-1 INHIBITORS | SCHERING AKTIENGESELLSCHAFT (DE) | 2003-10-02 | — | — | WO | disclosed |