Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 6/20 | 0.48 |
| ▸ | EPHA2 | P29317 | 1/20 | 0.48 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.48 |
| ▸ | EGFR | P00533 | 12/20 | 0.45 |
| ▸ | NSD2 | O96028 | 1/20 | 0.44 |
| ▸ | EHMT2 | Q96KQ7 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | IRAK1 | P51617 | 1/20 | 0.41 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7090020 | 0.89 | KDR (0.45) | KDREPHA2EPHB4EGFR | |
| SCHEMBL5828053 | 0.85 | KDR (0.48) | KDREPHA2EPHB4EGFRNSD2 | |
| SCHEMBL5828058 | 0.85 | KDR (0.48) | KDREPHA2EPHB4EGFRNSD2 | |
| SCHEMBL5828729 | 0.83 | EGFR (0.50) | KDREGFREHMT2MAPK1KDM4E | |
| SCHEMBL5828728 | 0.83 | EGFR (0.50) | KDREGFREHMT2MAPK1KDM4E | |
| SCHEMBL5828851 | 0.81 | KDM1A (0.49) | KDREGFREHMT2MAPK1KDM4E | |
| SCHEMBL5828850 | 0.81 | KDM1A (0.49) | KDREGFREHMT2MAPK1KDM4E | |
| SCHEMBL5828878 | 0.78 | KDR (0.51) | KDREPHA2EPHB4EGFRNSD2 | |
| SCHEMBL5828880 | 0.78 | KDR (0.51) | KDREPHA2EPHB4EGFRNSD2 | |
| SCHEMBL5828868 | 0.76 | HTT (0.48) | KDREGFRMAPK1KDM4ELMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1296973-A1 | GUANIDINE DERIVATIVES OF QUINAZOLINE AND QUINOLINE FOR USE IN THE TREATMENT OF AUTOIMMUNE DISEASES | AstraZeneca AB (SE) | 2003-04-02 | — | — | EP | disclosed |
| WO-2002000644-A1 | GUANIDINE DERIVATIVES OF QUINAZOLINE AND QUINOLINE FOR USE IN THE TREATMENT OF AUTOIMMUNE DISEASES | ASTRAZENECA AB (SE) | 2002-01-03 | — | — | WO | disclosed |