Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP27A1 | Q02318 | 1/20 | 0.37 |
| ▸ | CYP24A1 | Q07973 | 1/20 | 0.37 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.33 |
| ▸ | CYP2A13 | Q16696 | 1/20 | 0.33 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.32 |
| ▸ | ATM | Q13315 | 1/20 | 0.32 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.31 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.31 |
| ▸ | MMP1 | P03956 | 1/20 | 0.30 |
| ▸ | MMP2 | P08253 | 1/20 | 0.30 |
| ▸ | MMP9 | P14780 | 1/20 | 0.30 |
| ▸ | MMP12 | P39900 | 1/20 | 0.30 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.30 |
| ▸ | DRD2 | P14416 | 1/20 | 0.30 |
| ▸ | DRD3 | P35462 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7088298 | 0.84 | CYP27A1 (0.33) | CYP27A1CYP24A1SLC6A4CYP2A13ATM | |
| SCHEMBL17592658 | 0.81 | DDB1 (0.43) | — | |
| SCHEMBL8538917 | 0.78 | POLB (0.36) | PTGS1PTGS2 | |
| SCHEMBL1709368 | 0.73 | PPARG (0.35) | — | |
| SCHEMBL30825588 | 0.71 | PTGS1 (0.52) | CYP27A1CYP24A1ATMPTGS1PTGS2 | |
| SCHEMBL9296486 | 0.71 | PTGS1 (0.52) | CYP27A1CYP24A1ATMPTGS1PTGS2 | |
| SCHEMBL29169537 | 0.71 | PTGS1 (0.52) | CYP27A1CYP24A1ATMPTGS1PTGS2 | |
| SCHEMBL21754408 | 0.71 | ALDH1A1 (0.47) | — | |
| SCHEMBL17592593 | 0.70 | KMT2A (0.31) | — | |
| SCHEMBL30727008 | 0.70 | C5AR1 (0.36) | ATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1010694-B1 | Spiroimidazoline derivatives and their use as alpha2-adrenergic antagonists and monoamines-reuptake blockers | SERVIER LAB (FR) | 2003-08-06 | — | — | EP | disclosed |
| US-6172097-B1 | Spiro imidazoline compounds | ADIR ET COMPAGNIE (FR) | 2001-01-09 | — | — | US | disclosed |
| EP-1010694-A2 | Spiroimidazoline derivatives and their use as alpha2-adrenergic antagonists and monoamines-reuptake blockers | ADIR ET COMPAGNIE (FR) | 2000-06-21 | — | — | EP | disclosed |