Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.63 |
| ▸ | PRKDC | P78527 | 4/20 | 0.62 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.54 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.54 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.54 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.54 |
| ▸ | MYC | P01106 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 6/20 | 0.48 |
| ▸ | PKM | P14618 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 2/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | CA12 | O43570 | 1/20 | 0.44 |
| ▸ | CA1 | P00915 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5054826 | 0.92 | PRKDC (0.72) | GAAPRKDCPIK3CDPIK3CAPIK3CB | |
| SCHEMBL5054798 | 0.83 | PRKDC (0.55) | GAAPRKDCPIK3CDPIK3CAPIK3CB | |
| SCHEMBL5058325 | 0.82 | PRKDC (0.59) | PRKDCPIK3CDPIK3CAPIK3CBPIK3CG | |
| SCHEMBL26604551 | 0.82 | PRKDC (0.58) | PRKDCPIK3CDPIK3CAPIK3CBPIK3CG | |
| SCHEMBL5058586 | 0.81 | PRKDC (0.67) | PRKDCPIK3CDPIK3CAPIK3CBPIK3CG | |
| SCHEMBL9344830 | 0.81 | LGMN (0.54) | GAAPRKDCMAPTNPC1RAB9A | |
| SCHEMBL17113124 | 0.81 | GAA (0.51) | GAAPRKDCMAPTNPC1RAB9A | |
| SCHEMBL24849660 | 0.81 | PRKDC (0.55) | GAAPRKDCPIK3CDPIK3CAPIK3CB | |
| SCHEMBL18499422 | 0.80 | MYC (0.61) | GAAPRKDCPIK3CDPIK3CAPIK3CB | |
| SCHEMBL616715 | 0.80 | GAA (1.00) | GAAMYCMAPTSMN1; SMN2KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1351946-A2 | MATERIALS AND METHODS TO POTENTIATE CANCER TREATMENT | ICOS CORPORATION (US) | 2003-10-15 | — | — | EP | disclosed |
| WO-2002020500-A2 | MATERIALS AND METHODS TO POTENTIATE CANCER TREATMENT | ICOS CORPORATION (US) | 2002-03-14 | — | — | WO | disclosed |