Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LGMN | Q99538 | 3/20 | 0.54 |
| ▸ | IP6K1 | Q92551 | 1/20 | 0.51 |
| ▸ | PRKDC | P78527 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 5/20 | 0.50 |
| ▸ | NPC1 | O15118 | 3/20 | 0.50 |
| ▸ | RAB9A | P51151 | 2/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.49 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.49 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.48 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5054798 | 0.89 | PRKDC (0.55) | LGMNPRKDCMAPTNPC1RAB9A | |
| SCHEMBL20509930 | 0.87 | IP6K1 (0.68) | IP6K1MAPTNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL26604551 | 0.87 | PRKDC (0.58) | PRKDCMAPTNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL40467 | 0.86 | IP6K1 (0.66) | IP6K1MAPTNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL17827898 | 0.85 | LGMN (0.60) | LGMNIP6K1PRKDCMAPTSMN1; SMN2 | |
| SCHEMBL27170961 | 0.84 | SIRT6 (0.64) | IP6K1MAPTNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL5058325 | 0.84 | PRKDC (0.59) | PRKDCMAPTNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL340945 | 0.84 | PRKDC (0.67) | LGMNIP6K1PRKDCMAPTMEN1 | |
| SCHEMBL23662583 | 0.83 | MAPT (0.53) | PRKDCMAPTNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL31390780 | 0.83 | PRKDC (0.51) | PRKDCMAPTNPC1RAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023287730-A1 | TRICYCLIC COMPOUNDS | RECURIUM IP HOLDINGS, LLC (US) | 2023-01-19 | — | — | WO | disclosed |
| US-5308846-A | Vision defects, hypotensive agents | MERCK & CO., INC. (US) | 1994-05-03 | — | — | US | disclosed |
| US-5256667-A | Treating glaucoma; hypotensive agents | MERCK & CO., INC. (US) | 1993-10-26 | — | — | US | disclosed |
| US-5202322-A | Hypotensive agents; vision and nervous system disorders | MERCK & CO., INC. (US) | 1993-04-13 | — | — | US | disclosed |
| EP-0534706-A1 | Quinazolinones and pyridopyrimidinones useful as angiotensin II antagonists | MERCK & CO. INC. (US) | 1993-03-31 | — | — | EP | disclosed |