SCHEMBL7090320

SCHEMBL7090320

Brc1ccc(-c2nn(Cc3ccccc3)c3ccsc23)cc1

nearest known ligand 0.54

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 4/20 0.54
CYP1A2 P05177 2/20 0.54
CYP2C9 P11712 2/20 0.54
CYP2C19 P33261 2/20 0.54
CYP3A4 P08684 1/20 0.54
NPSR1 Q6W5P4 1/20 0.54
KMT2A Q03164 5/20 0.47
MEN1 O00255 4/20 0.47
GAA P10253 3/20 0.47
MAPT P10636 2/20 0.47
GALR3 O60755 1/20 0.47
NPY1R P25929 1/20 0.47
STAT3 P40763 1/20 0.47
NPY2R P49146 1/20 0.47
NR1H2 P55055 1/20 0.47
NR1H3 Q13133 1/20 0.47
ADORA3 P0DMS8 1/20 0.42
ADORA1 P30542 1/20 0.42
F2RL3 Q96RI0 1/20 0.39
ESR1 P03372 2/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7094721 0.90 ADORA1 (0.50) ALDH1A1CYP1A2CYP2C9CYP2C19CYP3A4
SCHEMBL7094701 0.87 ESR1 (0.53) ALDH1A1CYP1A2CYP2C9CYP2C19CYP3A4
SCHEMBL7096390 0.87 BTK (0.42) ALDH1A1CYP1A2CYP2C9CYP2C19CYP3A4
SCHEMBL6994778 0.84 ADORA1 (0.45) ALDH1A1CYP1A2CYP2C9CYP2C19CYP3A4
SCHEMBL7091163 0.82 F2RL3 (0.47) ALDH1A1CYP1A2CYP2C9CYP2C19CYP3A4
SCHEMBL7093526 0.78 KMT2A (0.50) ALDH1A1CYP1A2CYP2C9CYP2C19CYP3A4
SCHEMBL28982383 0.78 ALDH1A1 (0.71) ALDH1A1CYP1A2CYP2C9CYP2C19CYP3A4
SCHEMBL13618712 0.73 PDE5A (0.66) ALDH1A1CYP1A2CYP2C9CYP2C19CYP3A4
SCHEMBL2953485 0.72 PDE5A (0.67) ALDH1A1CYP1A2CYP2C9CYP2C19CYP3A4
SCHEMBL7500320 0.72 PDE5A (0.46) ALDH1A1CYP1A2CYP2C9CYP2C19CYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1289525-A2 TRICYCLIC PYRAZOLE DERIVATIVES AS PROTEIN KINASE INHIBITORS Abbott GmbH & Co. KG (DE) 2003-03-12 EP disclosed
US-6462036-B1 INHIBITING SIGNAL TRANSDUCTION BY MODULATING ACTIVITY OF RECEPTOR AND NONRECEPTOR TYROSINE AND SERINE/THREONINE KINASES TO REGULATE AND MODULATE ABNORMAL OR INAPPROPRIATE CELL PROLIFERATION, DIFFERENTIATION, OR METABOLISM BASF AKTIENGESELLSCHAFT (DE) 2002-10-08 US disclosed
WO-2001087846-A2 TRICYCLIC PYRAZOLE DERIVATIVES AS PROTEIN KINASE INHIBITORS ABBOTT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG & COMPANY KOMMANDITGESELLSCHAFT (DE) 2001-11-22 WO disclosed
EP-1127051-A2 TRICYCLIC PYRAZOLE DERIVATIVES BASF AKTIENGESELLSCHAFT (DE) 2001-08-29 EP disclosed
WO-2000027822-A2 TRICYCLIC PYRAZOLE DERIVATIVES BASF AKTIENGESELLSCHAFT (DE) 2000-05-18 WO disclosed