Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK10 | P53779 | 6/20 | 0.42 |
| ▸ | MAPK9 | P45984 | 4/20 | 0.42 |
| ▸ | PTK2 | Q05397 | 5/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | JAK2 | O60674 | 3/20 | 0.40 |
| ▸ | JAK1 | P23458 | 2/20 | 0.40 |
| ▸ | TYK2 | P29597 | 2/20 | 0.40 |
| ▸ | JAK3 | P52333 | 2/20 | 0.40 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.39 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.39 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.39 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.39 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.39 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.39 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.39 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.39 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5058349 | 0.88 | MAPK10 (0.49) | MAPK10MAPK9PTK2MAPTJAK2 | |
| SCHEMBL5055231 | 0.87 | MAPK10 (0.47) | MAPK10MAPTJAK2JAK1TYK2 | |
| SCHEMBL5059649 | 0.81 | PRKDC (0.55) | MAPTJAK2JAK1TYK2JAK3 | |
| SCHEMBL5059599 | 0.76 | KDM4E (0.50) | MAPTJAK2MEN1KMT2APRKDC | |
| SCHEMBL5065220 | 0.74 | L3MBTL1 (0.55) | MAPTJAK2JAK1TYK2HDAC1 | |
| SCHEMBL2088657 | 0.72 | JAK2 (0.47) | MAPTJAK2HDAC3HDAC4HDAC1 | |
| SCHEMBL1231926 | 0.72 | LGMN (0.54) | MAPK10PTK2MAPTJAK2JAK1 | |
| SCHEMBL9181962 | 0.68 | MAPT (0.38) | MAPTMEN1KMT2A | |
| SCHEMBL5058382 | 0.68 | PRKDC (0.72) | MAPK10PTK2MAPTJAK2JAK1 | |
| SCHEMBL30590429 | 0.68 | PRKDC (0.71) | MAPTHDAC3HDAC4HDAC1HDAC7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1351946-A2 | MATERIALS AND METHODS TO POTENTIATE CANCER TREATMENT | ICOS CORPORATION (US) | 2003-10-15 | — | — | EP | disclosed |
| WO-2002020500-A2 | MATERIALS AND METHODS TO POTENTIATE CANCER TREATMENT | ICOS CORPORATION (US) | 2002-03-14 | — | — | WO | disclosed |