Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKDC | P78527 | 2/20 | 0.56 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.56 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.56 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.56 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.53 |
| ▸ | MAPT | P10636 | 3/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.52 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.50 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.50 |
| ▸ | JAK2 | O60674 | 1/20 | 0.49 |
| ▸ | JAK1 | P23458 | 1/20 | 0.49 |
| ▸ | TYK2 | P29597 | 1/20 | 0.49 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.49 |
| ▸ | SLCO1B1 | Q9Y6L6 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.49 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5063561 | 0.94 | PRKDC (0.62) | PRKDCPIK3CDPIK3CAPIK3CBPIK3CG | |
| SCHEMBL5059683 | 0.90 | PRKDC (0.67) | PRKDCPIK3CDPIK3CAPIK3CBPIK3CG | |
| SCHEMBL5058532 | 0.83 | PRKDC (0.55) | PRKDCPIK3CDPIK3CAPIK3CBPIK3CG | |
| SCHEMBL17774907 | 0.79 | JAK2 (0.58) | SMN1; SMN2MAPTJAK2JAK1TYK2 | |
| SCHEMBL5065271 | 0.79 | MAPT (0.65) | PRKDCPIK3CDPIK3CAPIK3CBPIK3CG | |
| SCHEMBL5054845 | 0.79 | PRKDC (0.61) | PRKDCPIK3CDPIK3CAPIK3CBPIK3CG | |
| SCHEMBL5065220 | 0.78 | L3MBTL1 (0.55) | SMN1; SMN2MAPTJAK2JAK1TYK2 | |
| SCHEMBL5058430 | 0.78 | SMN1; SMN2 (0.61) | PRKDCPIK3CDPIK3CAPIK3CBPIK3CG | |
| SCHEMBL7090867 | 0.76 | PRKDC (0.46) | PRKDCPIK3CDPIK3CAPIK3CBPIK3CG | |
| SCHEMBL18553757 | 0.76 | CCNC (0.53) | PRKDCPIK3CDPIK3CAPIK3CBPIK3CG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1351946-A2 | MATERIALS AND METHODS TO POTENTIATE CANCER TREATMENT | ICOS CORPORATION (US) | 2003-10-15 | — | — | EP | disclosed |
| WO-2002020500-A2 | MATERIALS AND METHODS TO POTENTIATE CANCER TREATMENT | ICOS CORPORATION (US) | 2002-03-14 | — | — | WO | disclosed |