Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKDC | P78527 | 3/20 | 0.46 |
| ▸ | PIK3CB | P42338 | 3/20 | 0.46 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.46 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.46 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.46 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.43 |
| ▸ | KLK1 | P06870 | 1/20 | 0.43 |
| ▸ | HTR6 | P50406 | 1/20 | 0.43 |
| ▸ | JAK2 | O60674 | 1/20 | 0.42 |
| ▸ | JAK1 | P23458 | 1/20 | 0.42 |
| ▸ | TYK2 | P29597 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.40 |
| ▸ | NAPEPLD | Q6IQ20 | 1/20 | 0.40 |
| ▸ | STAT6 | P42226 | 1/20 | 0.40 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.39 |
| ▸ | AURKA | O14965 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5063561 | 0.82 | PRKDC (0.62) | PRKDCPIK3CBPIK3CAPIK3CDPIK3CG | |
| SCHEMBL7090447 | 0.76 | PRKDC (0.56) | PRKDCPIK3CBPIK3CAPIK3CDPIK3CG | |
| SCHEMBL5054826 | 0.74 | PRKDC (0.72) | PRKDCPIK3CBPIK3CAPIK3CDPIK3CG | |
| SCHEMBL5058382 | 0.74 | PRKDC (0.72) | PRKDCPIK3CBPIK3CAPIK3CDPIK3CG | |
| SCHEMBL5059642 | 0.72 | PRKDC (0.71) | PRKDCPIK3CBPIK3CAPIK3CDPIK3CG | |
| SCHEMBL5058532 | 0.72 | PRKDC (0.55) | PRKDCPIK3CBPIK3CAPIK3CDPIK3CG | |
| SCHEMBL11921365 | 0.71 | PRKDC (0.68) | PRKDCPIK3CBPIK3CAPIK3CDPIK3CG | |
| SCHEMBL4992024 | 0.71 | PRKDC (0.73) | PRKDCPIK3CBPIK3CAPIK3CDPIK3CG | |
| SCHEMBL17774907 | 0.71 | JAK2 (0.58) | KLKB1KLK1JAK2JAK1TYK2 | |
| SCHEMBL7089916 | 0.71 | GAA (0.63) | PRKDCPIK3CBPIK3CAPIK3CDPIK3CG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1351946-A2 | MATERIALS AND METHODS TO POTENTIATE CANCER TREATMENT | ICOS CORPORATION (US) | 2003-10-15 | — | — | EP | disclosed |
| WO-2002020500-A2 | MATERIALS AND METHODS TO POTENTIATE CANCER TREATMENT | ICOS CORPORATION (US) | 2002-03-14 | — | — | WO | disclosed |