Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRA | P10827 | 14/20 | 0.56 |
| ▸ | THRB | P10828 | 14/20 | 0.56 |
| ▸ | HTR2A | P28223 | 2/20 | 0.39 |
| ▸ | HTR2C | P28335 | 1/20 | 0.39 |
| ▸ | HTR2B | P41595 | 1/20 | 0.39 |
| ▸ | LTA4H | P09960 | 1/20 | 0.38 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.38 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.38 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.38 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.38 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.38 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.38 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.38 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.38 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6511402 | 0.87 | THRA (0.57) | THRATHRBHTR2AHTR2CHTR2B | |
| SCHEMBL6515758 | 0.86 | THRA (0.60) | THRATHRBHTR2AHTR2CHTR2B | |
| SCHEMBL7089721 | 0.85 | THRA (0.45) | THRATHRBHTR2ALTA4HPLA2G2A | |
| SCHEMBL7091904 | 0.84 | THRA (0.66) | THRATHRBHTR2AHTR2CHTR2B | |
| SCHEMBL7087694 | 0.84 | THRA (0.58) | THRATHRBHTR2AHTR2CHTR2B | |
| SCHEMBL7086230 | 0.83 | THRA (0.60) | THRATHRBHTR2AHTR2CHTR2B | |
| SCHEMBL7088599 | 0.83 | THRA (0.45) | THRATHRBHTR2AHTR2CHTR2B | |
| SCHEMBL6515497 | 0.83 | THRA (0.58) | THRATHRBHTR2AHTR2CHTR2B | |
| SCHEMBL7088921 | 0.83 | THRA (0.44) | THRATHRB | |
| SCHEMBL22646577 | 0.80 | THRA (0.52) | THRATHRBHTR2AHTR2CHTR2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1268422-A1 | INDOLES FOR TREATING DISEASES THAT CAN BE TREATED USING THYROID HORMONES | Bayer Aktiengesellschaft (DE) | 2003-01-02 | — | — | EP | disclosed |
| WO-2001070687-A1 | INDOLES FOR TREATING DISEASES THAT CAN BE TREATED USING THYROID HORMONES | BAYER AKTIENGESELLSCHAFT (DE) | 2001-09-27 | — | — | WO | disclosed |