Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRA | P10827 | 13/20 | 0.66 |
| ▸ | THRB | P10828 | 13/20 | 0.66 |
| ▸ | KIF11 | P52732 | 3/20 | 0.41 |
| ▸ | HTR2A | P28223 | 2/20 | 0.38 |
| ▸ | HTR2C | P28335 | 1/20 | 0.37 |
| ▸ | HTR2B | P41595 | 1/20 | 0.37 |
| ▸ | LTA4H | P09960 | 1/20 | 0.36 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7091134 | 0.90 | THRA (0.56) | THRATHRBKIF11HTR2AHTR2C | |
| SCHEMBL7085460 | 0.86 | THRA (0.48) | THRATHRBKIF11HTR2ALTA4H | |
| SCHEMBL7084815 | 0.85 | THRA (0.50) | THRATHRBKIF11HTR2AHTR2C | |
| SCHEMBL6511402 | 0.84 | THRA (0.57) | THRATHRBHTR2AHTR2CHTR2B | |
| SCHEMBL7090515 | 0.84 | THRA (0.56) | THRATHRBHTR2AHTR2CHTR2B | |
| SCHEMBL6515758 | 0.84 | THRA (0.60) | THRATHRBHTR2AHTR2CHTR2B | |
| SCHEMBL7082352 | 0.83 | THRA (0.69) | THRATHRBHTR2AHTR2CHTR2B | |
| SCHEMBL6516990 | 0.83 | THRA (0.74) | THRATHRBHTR2AHTR2CHTR2B | |
| SCHEMBL7088959 | 0.81 | LTA4H (0.48) | THRATHRBHTR2ALTA4HPLA2G2A | |
| SCHEMBL7087694 | 0.81 | THRA (0.58) | THRATHRBHTR2AHTR2CHTR2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1268422-A1 | INDOLES FOR TREATING DISEASES THAT CAN BE TREATED USING THYROID HORMONES | Bayer Aktiengesellschaft (DE) | 2003-01-02 | — | — | EP | disclosed |
| WO-2001070687-A1 | INDOLES FOR TREATING DISEASES THAT CAN BE TREATED USING THYROID HORMONES | BAYER AKTIENGESELLSCHAFT (DE) | 2001-09-27 | — | — | WO | disclosed |