Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | THRA | P10827 | 6/20 | 0.41 |
| ▸ | THRB | P10828 | 6/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.40 |
| ▸ | HTT | P42858 | 3/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | TP53 | P04637 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.39 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.39 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.39 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.39 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.39 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.39 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.39 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.39 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 6/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7089688 | 0.89 | MAPT (0.43) | MAPTTHRATHRBSMN1; SMN2HTT | |
| SCHEMBL7093571 | 0.85 | MAPT (0.53) | MAPTTHRATHRBSMN1; SMN2HTT | |
| SCHEMBL7091960 | 0.85 | MAPT (0.55) | MAPTTHRATHRBSMN1; SMN2HTT | |
| SCHEMBL7090124 | 0.84 | MAPT (0.48) | MAPTTHRATHRBSMN1; SMN2HTT | |
| SCHEMBL7089970 | 0.83 | MAPT (0.45) | MAPTTHRATHRBSMN1; SMN2HTT | |
| SCHEMBL7092628 | 0.82 | MAPT (0.67) | MAPTTHRATHRBSMN1; SMN2HTT | |
| SCHEMBL7090098 | 0.81 | MAPT (0.41) | MAPTTHRATHRBSMN1; SMN2HTT | |
| SCHEMBL6512575 | 0.81 | THRA (0.60) | MAPTTHRATHRBSMN1; SMN2HTT | |
| SCHEMBL7090097 | 0.81 | MAPT (0.66) | MAPTSMN1; SMN2HTTLMNATP53 | |
| SCHEMBL7093569 | 0.79 | MAPT (0.49) | MAPTSMN1; SMN2HTTLMNATP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1347959-A1 | INDOLE DERIVATIVES AS LIGANDS OF THYROID RECEPTORS | Bayer Aktiengesellschaft (DE) | 2003-10-01 | — | — | EP | disclosed |
| WO-2002051805-A1 | INDOLE DERIVATIVES AS LIGANDS OF THYROID RECEPTORS | BAYER AKTIENGESELLSCHAFT (DE) | 2002-07-04 | — | — | WO | disclosed |