Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 3/20 | 0.45 |
| ▸ | HTR1B | P28222 | 3/20 | 0.45 |
| ▸ | HTR1D | P28221 | 1/20 | 0.45 |
| ▸ | HTR6 | P50406 | 2/20 | 0.43 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | THRA | P10827 | 6/20 | 0.41 |
| ▸ | THRB | P10828 | 6/20 | 0.41 |
| ▸ | BCHE | P06276 | 2/20 | 0.38 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7087920 | 0.99 | HTR1A (0.44) | HTR1AHTR1BHTR1DHTR6SLC6A4 | |
| SCHEMBL7089629 | 0.93 | HTR1B (0.42) | HTR1AHTR1BHTR1DHTR6SLC6A4 | |
| SCHEMBL7088286 | 0.92 | HTR1A (0.41) | HTR1AHTR1BHTR1DHTR6SLC6A4 | |
| SCHEMBL7084348 | 0.92 | SLC6A4 (0.41) | HTR1AHTR1BHTR1DHTR6SLC6A4 | |
| SCHEMBL7090640 | 0.90 | SLC6A4 (0.41) | HTR1AHTR1BHTR1DHTR6SLC6A4 | |
| SCHEMBL7088304 | 0.90 | SLC6A4 (0.39) | HTR1AHTR1BHTR1DHTR6SLC6A4 | |
| SCHEMBL7090894 | 0.90 | THRA (0.41) | HTR1AHTR1BHTR1DHTR6SLC6A4 | |
| SCHEMBL7093058 | 0.88 | THRA (0.41) | HTR1AHTR1BHTR1DHTR6SLC6A4 | |
| SCHEMBL7088380 | 0.88 | SLC6A4 (0.40) | HTR1AHTR1BHTR1DHTR6SLC6A4 | |
| SCHEMBL7087438 | 0.88 | SLC6A4 (0.42) | HTR1AHTR1BHTR1DHTR6SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1347959-A1 | INDOLE DERIVATIVES AS LIGANDS OF THYROID RECEPTORS | Bayer Aktiengesellschaft (DE) | 2003-10-01 | — | — | EP | disclosed |
| WO-2002051805-A1 | INDOLE DERIVATIVES AS LIGANDS OF THYROID RECEPTORS | BAYER AKTIENGESELLSCHAFT (DE) | 2002-07-04 | — | — | WO | disclosed |