Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LIMK2 | P53671 | 1/20 | 0.34 |
| ▸ | MET | P08581 | 1/20 | 0.33 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.32 |
| ▸ | HRH1 | P35367 | 1/20 | 0.32 |
| ▸ | COMT | P21964 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 3/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | PARP1 | P09874 | 1/20 | 0.31 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.31 |
| ▸ | MAP2K4 | P45985 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 2/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.31 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.31 |
| ▸ | ENPP1 | P22413 | 1/20 | 0.31 |
| ▸ | TNKS | O95271 | 1/20 | 0.31 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7095837 | 0.78 | MEN1 (0.51) | ROCK1MEN1KMT2AMAPK1ALDH1A1 | |
| SCHEMBL7097681 | 0.77 | FGFR2 (0.32) | ROCK1MEN1KMT2APTPN1MAPT | |
| SCHEMBL7092191 | 0.76 | CXCR4 (0.51) | ROCK1MEN1KMT2AMAPK1ALDH1A1 | |
| SCHEMBL7097039 | 0.75 | EGFR (0.42) | ROCK1MEN1KMT2AALDH1A1RAB9A | |
| SCHEMBL7000848 | 0.75 | ALDH1A1 (0.49) | ROCK1MEN1KMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL7886097 | 0.74 | NOS2 (0.52) | MEN1KMT2ASMN1; SMN2MAP2K4RAB9A | |
| SCHEMBL7096045 | 0.73 | LRRK2 (0.43) | ROCK1MAPK1ENPP1 | |
| SCHEMBL7090318 | 0.72 | CSF1R (0.41) | ROCK1MEN1KMT2AMAPK1ALDH1A1 | |
| SCHEMBL7094698 | 0.72 | PDPK1 (0.43) | MEN1KMT2AMAPK1ALDH1A1PTPN1 | |
| SCHEMBL7096389 | 0.72 | MAPT (0.41) | ROCK1MEN1KMT2AALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1268437-A1 | INHIBITORS OF PROTEIN KINASES | Knoll GmbH (DE) | 2003-01-02 | — | — | EP | disclosed |
| WO-2002030908-A1 | INHIBITORS OF PROTEIN KINASES | KNOLL GMBH (DE) | 2002-04-18 | — | — | WO | disclosed |