Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNFRSF1A | P19438 | 13/20 | 0.53 |
| ▸ | TUBB4A | P04350 | 3/20 | 0.48 |
| ▸ | TUBB | P07437 | 3/20 | 0.48 |
| ▸ | TUBA3C | P0DPH7 | 3/20 | 0.48 |
| ▸ | TUBA1B | P68363 | 3/20 | 0.48 |
| ▸ | TUBA4A | P68366 | 3/20 | 0.48 |
| ▸ | TUBB4B | P68371 | 3/20 | 0.48 |
| ▸ | TUBB3 | Q13509 | 3/20 | 0.48 |
| ▸ | TUBB2A | Q13885 | 3/20 | 0.48 |
| ▸ | TUBB8 | Q3ZCM7 | 3/20 | 0.48 |
| ▸ | TUBA3E | Q6PEY2 | 3/20 | 0.48 |
| ▸ | TUBA1A | Q71U36 | 3/20 | 0.48 |
| ▸ | TUBA1C | Q9BQE3 | 3/20 | 0.48 |
| ▸ | TUBB6 | Q9BUF5 | 3/20 | 0.48 |
| ▸ | TUBB2B | Q9BVA1 | 3/20 | 0.48 |
| ▸ | TUBB1 | Q9H4B7 | 3/20 | 0.48 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7087083 | 0.91 | TNFRSF1A (0.54) | TNFRSF1AKDM4EALDH1A1MEN1KMT2A | |
| SCHEMBL7087566 | 0.85 | TNFRSF1A (0.55) | TNFRSF1ATUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL7090129 | 0.83 | TNFRSF1A (0.55) | TNFRSF1ATUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL1307573 | 0.78 | TUBB4A (0.69) | TNFRSF1ATUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL7090845 | 0.74 | TNFRSF1A (0.49) | TNFRSF1ATUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL1308179 | 0.72 | TUBB4A (0.67) | TNFRSF1ATUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL5576279 | 0.72 | TNFRSF1A (0.69) | TNFRSF1AABCB1KDM4EALDH1A1MEN1 | |
| SCHEMBL1308143 | 0.71 | TUBB4A (0.66) | TNFRSF1ATUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL4680908 | 0.71 | TNFRSF1A (0.57) | TNFRSF1ATUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL7121640 | 0.70 | TNFRSF1A (0.64) | TNFRSF1AMAPTHPGDSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1330448-A2 | 1,3-BIS-(SUBSTITUTED-PHENYL)-2-PROPEN-1-ONES AND THEIR USE TO TREAT VCAM-1 MEDIATED DISORDERS | Atherogenics, Inc. (US) | 2003-07-30 | — | — | EP | disclosed |
| WO-2001098291-A2 | 1,3-BIS-(SUBSTITUTED-PHENYL)-2-PROPEN-1-ONES AND THEIR USE TO TREAT VCAM-1 MEDIATED DISORDERS | ATHEROGENICS, INC. (US) | 2001-12-27 | — | — | WO | disclosed |