Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNFRSF1A | P19438 | 14/20 | 0.64 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.44 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7124922 | 0.84 | TNFRSF1A (0.61) | TNFRSF1ASMN1; SMN2NPC1HPGDRAB9A | |
| SCHEMBL5576253 | 0.78 | TNFRSF1A (1.00) | TNFRSF1A | |
| SCHEMBL5576256 | 0.78 | TNFRSF1A (1.00) | TNFRSF1A | |
| SCHEMBL7090129 | 0.78 | TNFRSF1A (0.55) | TNFRSF1AMAPT | |
| SCHEMBL6986840 | 0.77 | TNFRSF1A (0.65) | TNFRSF1AHPGDMAPT | |
| SCHEMBL7087083 | 0.76 | TNFRSF1A (0.54) | TNFRSF1AHDAC1HDAC2MAPT | |
| SCHEMBL6990108 | 0.76 | TNFRSF1A (0.60) | TNFRSF1AHDAC1HDAC2RAB9A | |
| SCHEMBL6092896 | 0.72 | TNFRSF1A (0.52) | TNFRSF1AHDAC1HDAC2 | |
| SCHEMBL7087566 | 0.72 | TNFRSF1A (0.55) | TNFRSF1AHDAC1HDAC2 | |
| SCHEMBL7090922 | 0.70 | TNFRSF1A (0.53) | TNFRSF1ASMN1; SMN2HPGDMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2003033662-A2 | PROTECTION AGAINST OXIDATIVE STRESS AND INFLAMMATION BY A CYTOPROTECTIVE RESPONSE ELEMENT | ATHEROGENICS, INC. (US) | 2003-04-24 | — | — | WO | disclosed |