Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.59 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.51 |
| ▸ | GAA | P10253 | 2/20 | 0.50 |
| ▸ | MGAM | O43451 | 1/20 | 0.50 |
| ▸ | SI | P14410 | 1/20 | 0.50 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.50 |
| ▸ | FAAH | O00519 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | ACHE | P22303 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | GLA | P06280 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29328685 | 0.91 | LMNA (0.69) | LMNAGAAFAAHALDH1A1CYP3A4 | |
| SCHEMBL27949963 | 0.86 | GAA (0.50) | LMNAGAAMGAMSIMGAM2 | |
| SCHEMBL27842352 | 0.86 | MGAM (0.46) | LMNATDP1GAAMGAMSI | |
| SCHEMBL10709895 | 0.84 | GAA (0.56) | TDP1GAAMGAMSIMGAM2 | |
| SCHEMBL27873086 | 0.83 | TP53 (0.45) | LMNATDP1GAAMGAMSI | |
| SCHEMBL28048831 | 0.83 | GAA (0.54) | TDP1GAAMGAMSIMGAM2 | |
| SCHEMBL28781611 | 0.83 | GAA (0.54) | TDP1GAAMGAMSIMGAM2 | |
| Ammonia Solution, Strong SCHEMBL27849187 | 0.83 | GAA (0.54) | TDP1GAAMGAMSIMGAM2 | |
| SCHEMBL308933 | 0.83 | LMNA (0.62) | LMNATDP1L3MBTL1GAAMAPK1 | |
| SCHEMBL11708911 | 0.82 | LMNA (0.67) | LMNATDP1L3MBTL1GAAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1339688-A1 | N-TYPE CALCIUM CHANNEL ANTAGONISTS FOR THE TREATMENT OF PAIN | AstraZeneca AB (SE) | 2003-09-03 | — | — | EP | disclosed |
| WO-2002036567-A1 | N-TYPE CALCIUM CHANNEL ANTAGONISTS FOR THE TREATMENT OF PAIN | ASTRAZENECA AB (SE) | 2002-05-10 | — | — | WO | disclosed |