Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNE2 | O96020 | 16/20 | 0.69 |
| ▸ | CCNE1 | P24864 | 16/20 | 0.69 |
| ▸ | CDK2 | P24941 | 16/20 | 0.69 |
| ▸ | CDK4 | P11802 | 16/20 | 0.69 |
| ▸ | CCND1 | P24385 | 16/20 | 0.69 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.60 |
| ▸ | IDO1 | P14902 | 1/20 | 0.57 |
| ▸ | PTPRC | P08575 | 1/20 | 0.51 |
| ▸ | PTPRF | P10586 | 1/20 | 0.51 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.51 |
| ▸ | CDC25B | P30305 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4807497 | 0.83 | CDK4 (0.60) | CCNE2CCNE1CDK2CDK4CCND1 | |
| SCHEMBL7090159 | 0.79 | CDK4 (0.71) | CCNE2CCNE1CDK2CDK4CCND1 | |
| SCHEMBL7146443 | 0.77 | CDK4 (0.68) | CCNE2CCNE1CDK2CDK4CCND1 | |
| SCHEMBL4816704 | 0.77 | CDK4 (0.68) | CCNE2CCNE1CDK2CDK4CCND1 | |
| SCHEMBL7145484 | 0.77 | CDK4 (0.68) | CCNE2CCNE1CDK2CDK4CCND1 | |
| SCHEMBL7140772 | 0.76 | CDK4 (0.70) | CCNE2CCNE1CDK2CDK4CCND1 | |
| SCHEMBL7000003 | 0.76 | CHEK1 (0.64) | CDK2MAPK1 | |
| SCHEMBL7148608 | 0.76 | CDK4 (0.66) | CCNE2CCNE1CDK2CDK4CCND1 | |
| SCHEMBL1752774 | 0.75 | MAPK1 (0.64) | MAPK1IDO1 | |
| SCHEMBL22317938 | 0.74 | MAP2K4 (0.49) | CCNE2CCNE1CDK2CDK4CCND1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1289525-A2 | TRICYCLIC PYRAZOLE DERIVATIVES AS PROTEIN KINASE INHIBITORS | Abbott GmbH & Co. KG (DE) | 2003-03-12 | — | — | EP | disclosed |
| US-6462036-B1 | INHIBITING SIGNAL TRANSDUCTION BY MODULATING ACTIVITY OF RECEPTOR AND NONRECEPTOR TYROSINE AND SERINE/THREONINE KINASES TO REGULATE AND MODULATE ABNORMAL OR INAPPROPRIATE CELL PROLIFERATION, DIFFERENTIATION, OR METABOLISM | BASF AKTIENGESELLSCHAFT (DE) | 2002-10-08 | — | — | US | disclosed |
| WO-2001087846-A2 | TRICYCLIC PYRAZOLE DERIVATIVES AS PROTEIN KINASE INHIBITORS | ABBOTT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG & COMPANY KOMMANDITGESELLSCHAFT (DE) | 2001-11-22 | — | — | WO | disclosed |
| EP-1127051-A2 | TRICYCLIC PYRAZOLE DERIVATIVES | BASF AKTIENGESELLSCHAFT (DE) | 2001-08-29 | — | — | EP | disclosed |
| WO-2000027822-A2 | TRICYCLIC PYRAZOLE DERIVATIVES | BASF AKTIENGESELLSCHAFT (DE) | 2000-05-18 | — | — | WO | disclosed |