Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK4 | P11802 | 12/20 | 0.71 |
| ▸ | CCND1 | P24385 | 11/20 | 0.71 |
| ▸ | CDK2 | P24941 | 9/20 | 0.71 |
| ▸ | CCNE2 | O96020 | 8/20 | 0.71 |
| ▸ | CCNE1 | P24864 | 8/20 | 0.71 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.49 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.49 |
| ▸ | KDR | P35968 | 1/20 | 0.47 |
| ▸ | ATM | Q13315 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7148608 | 0.89 | CDK4 (0.66) | CDK4CCND1CDK2CCNE2CCNE1 | |
| SCHEMBL4816704 | 0.87 | CDK4 (0.68) | CDK4CCND1CDK2CCNE2CCNE1 | |
| SCHEMBL7145484 | 0.87 | CDK4 (0.68) | CDK4CCND1CDK2CCNE2CCNE1 | |
| SCHEMBL7146443 | 0.87 | CDK4 (0.68) | CDK4CCND1CDK2CCNE2CCNE1 | |
| SCHEMBL12856433 | 0.86 | CDK2 (0.55) | CDK4CCND1CDK2CCNE2CCNE1 | |
| SCHEMBL20035506 | 0.85 | ALDH1A1 (0.53) | CDK4CCND1CDK2CCNE2CCNE1 | |
| SCHEMBL18292498 | 0.81 | NPSR1 (0.54) | CDK4CCND1CDK2CCNE2CCNE1 | |
| SCHEMBL7091188 | 0.79 | CCNE2 (0.69) | CDK4CCND1CDK2CCNE2CCNE1 | |
| SCHEMBL7140772 | 0.77 | CDK4 (0.70) | CDK4CCND1CDK2CCNE2CCNE1 | |
| SCHEMBL7147568 | 0.77 | CDK4 (0.67) | CDK4CCND1CDK2CCNE2CCNE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6534655-B1 | Administering as anti-angiogenic compounds or to inhibit vascular hyperpermeability | BASF AKTIENGESELLSCHAFT (DE) | 2003-03-18 | — | — | US | disclosed |
| EP-1289525-A2 | TRICYCLIC PYRAZOLE DERIVATIVES AS PROTEIN KINASE INHIBITORS | Abbott GmbH & Co. KG (DE) | 2003-03-12 | — | — | EP | disclosed |
| US-6462036-B1 | INHIBITING SIGNAL TRANSDUCTION BY MODULATING ACTIVITY OF RECEPTOR AND NONRECEPTOR TYROSINE AND SERINE/THREONINE KINASES TO REGULATE AND MODULATE ABNORMAL OR INAPPROPRIATE CELL PROLIFERATION, DIFFERENTIATION, OR METABOLISM | BASF AKTIENGESELLSCHAFT (DE) | 2002-10-08 | — | — | US | disclosed |
| WO-2001087846-A2 | TRICYCLIC PYRAZOLE DERIVATIVES AS PROTEIN KINASE INHIBITORS | ABBOTT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG & COMPANY KOMMANDITGESELLSCHAFT (DE) | 2001-11-22 | — | — | WO | disclosed |
| EP-1127051-A2 | TRICYCLIC PYRAZOLE DERIVATIVES | BASF AKTIENGESELLSCHAFT (DE) | 2001-08-29 | — | — | EP | disclosed |
| EP-1021182-A1 | INDENO[1,2-C] PYRAZOLE DERIVATIVES FOR INHIBITING TYROSINE KINASE ACTIVITY | BASF AKTIENGESELLSCHAFT (DE) | 2000-07-26 | — | — | EP | disclosed |
| WO-2000027822-A2 | TRICYCLIC PYRAZOLE DERIVATIVES | BASF AKTIENGESELLSCHAFT (DE) | 2000-05-18 | — | — | WO | disclosed |
| WO-1999017770-A1 | INDENO[1,2-C]PYRAZOLE DERIVATIVES FOR INHIBITING TYROSINE KINASE ACTIVITY | BASF AKTIENGESELLSCHAFT (DE) | 1999-04-15 | — | — | WO | disclosed |