Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK4 | P11802 | 11/20 | 0.70 |
| ▸ | CCND1 | P24385 | 10/20 | 0.70 |
| ▸ | CDK2 | P24941 | 8/20 | 0.70 |
| ▸ | CCNE2 | O96020 | 7/20 | 0.70 |
| ▸ | CCNE1 | P24864 | 7/20 | 0.70 |
| ▸ | PDE4A | P27815 | 2/20 | 0.59 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.59 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.59 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | USP2 | O75604 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.48 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7147568 | 0.87 | CDK4 (0.67) | CDK4CCND1CDK2CCNE2CCNE1 | |
| SCHEMBL7090323 | 0.81 | PDE4A (0.49) | CDK4CCND1CDK2CCNE2CCNE1 | |
| SCHEMBL7090322 | 0.81 | PDE4A (0.49) | CDK4CCND1CDK2CCNE2CCNE1 | |
| SCHEMBL4024853 | 0.79 | CCNE2 (0.76) | CDK4CCND1CDK2CCNE2CCNE1 | |
| SCHEMBL7090159 | 0.77 | CDK4 (0.71) | CDK4CCND1CDK2CCNE2CCNE1 | |
| SCHEMBL7091188 | 0.76 | CCNE2 (0.69) | CDK4CCND1CDK2CCNE2CCNE1 | |
| SCHEMBL7145484 | 0.75 | CDK4 (0.68) | CDK4CCND1CDK2CCNE2CCNE1 | |
| SCHEMBL4816704 | 0.75 | CDK4 (0.68) | CDK4CCND1CDK2CCNE2CCNE1 | |
| SCHEMBL7146443 | 0.75 | CDK4 (0.68) | CDK4CCND1CDK2CCNE2CCNE1 | |
| SCHEMBL6477699 | 0.74 | PDE4A (1.00) | PDE4APDE4BPDE4CPDE4DKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6534655-B1 | Administering as anti-angiogenic compounds or to inhibit vascular hyperpermeability | BASF AKTIENGESELLSCHAFT (DE) | 2003-03-18 | — | — | US | disclosed |
| EP-1021182-A1 | INDENO[1,2-C] PYRAZOLE DERIVATIVES FOR INHIBITING TYROSINE KINASE ACTIVITY | BASF AKTIENGESELLSCHAFT (DE) | 2000-07-26 | — | — | EP | disclosed |
| WO-1999017770-A1 | INDENO[1,2-C]PYRAZOLE DERIVATIVES FOR INHIBITING TYROSINE KINASE ACTIVITY | BASF AKTIENGESELLSCHAFT (DE) | 1999-04-15 | — | — | WO | disclosed |