Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 5/20 | 0.58 |
| ▸ | CHEK1 | O14757 | 6/20 | 0.56 |
| ▸ | NAMPT | P43490 | 3/20 | 0.53 |
| ▸ | CDK2 | P24941 | 2/20 | 0.52 |
| ▸ | CDK1 | P06493 | 1/20 | 0.52 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.51 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.51 |
| ▸ | SGK1 | O00141 | 1/20 | 0.49 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.49 |
| ▸ | PRKCG | P05129 | 1/20 | 0.49 |
| ▸ | AKT1 | P31749 | 1/20 | 0.49 |
| ▸ | AKT2 | P31751 | 1/20 | 0.49 |
| ▸ | MARK2 | Q7KZI7 | 1/20 | 0.49 |
| ▸ | AKT3 | Q9Y243 | 1/20 | 0.49 |
| ▸ | KIT | P10721 | 2/20 | 0.48 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.48 |
| ▸ | CDK4 | P11802 | 1/20 | 0.48 |
| ▸ | CCND1 | P24385 | 1/20 | 0.48 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.48 |
| ▸ | FLT1 | P17948 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7701855 | 0.93 | NAMPT (0.64) | KDRCHEK1NAMPTCDK2CDK1 | |
| SCHEMBL7701559 | 0.91 | NAMPT (0.52) | KDRCHEK1NAMPTCDK2CDK1 | |
| SCHEMBL7701963 | 0.87 | CHEK1 (0.57) | KDRCHEK1CDK2CDK1KCNH2 | |
| SCHEMBL7705692 | 0.86 | CHEK1 (0.62) | KDRCHEK1CDK2CDK1KIT | |
| SCHEMBL7701135 | 0.86 | KMT2A (0.53) | CHEK1 | |
| SCHEMBL7702362 | 0.85 | KDR (0.52) | KDRCHEK1NAMPTCDK2CDK1 | |
| SCHEMBL7705309 | 0.85 | KDR (0.69) | KDRCHEK1NAMPTCDK2CDK1 | |
| SCHEMBL7701122 | 0.83 | CHEK1 (0.48) | KDRCHEK1NAMPTCDK2CDK1 | |
| SCHEMBL7701166 | 0.83 | CHEK1 (0.53) | KDRCHEK1CDK2CDK1KCNH2 | |
| SCHEMBL7091508 | 0.82 | KDR (0.56) | KDRCHEK1CDK2CDK1SGK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6462036-B1 | INHIBITING SIGNAL TRANSDUCTION BY MODULATING ACTIVITY OF RECEPTOR AND NONRECEPTOR TYROSINE AND SERINE/THREONINE KINASES TO REGULATE AND MODULATE ABNORMAL OR INAPPROPRIATE CELL PROLIFERATION, DIFFERENTIATION, OR METABOLISM | BASF AKTIENGESELLSCHAFT (DE) | 2002-10-08 | — | — | US | disclosed |