Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 5/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.37 |
| ▸ | POLB | P06746 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.34 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.34 |
| ▸ | PRMT8 | Q9NR22 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | PSMB1 | P20618 | 1/20 | 0.33 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.33 |
| ▸ | PSMB2 | P49721 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7088927 | 0.98 | HRH3 (0.42) | HRH3MAPTPOLBALDH1A1L3MBTL1 | |
| SCHEMBL29889633 | 0.93 | HRH3 (0.42) | HRH3MAPTPOLBALDH1A1L3MBTL1 | |
| SCHEMBL4989467 | 0.83 | POLB (0.44) | POLBSMN1; SMN2 | |
| SCHEMBL4993541 | 0.81 | POLB (0.42) | POLBSMN1; SMN2 | |
| SCHEMBL23056803 | 0.75 | HRH3 (0.42) | HRH3MAPTPOLBALDH1A1L3MBTL1 | |
| SCHEMBL7091824 | 0.74 | HRH3 (0.30) | HRH3 | |
| SCHEMBL23056837 | 0.73 | HRH3 (0.46) | HRH3MAPTPOLBALDH1A1L3MBTL1 | |
| SCHEMBL7623444 | 0.72 | SIGMAR1 (0.55) | HRH3POLBALDH1A1LMNATSHR | |
| SCHEMBL11209430 | 0.71 | HRH3 (0.44) | HRH3MAPTPOLBALDH1A1L3MBTL1 | |
| SCHEMBL23011368 | 0.70 | CYP2D6 (0.37) | SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1270562-A2 | Cyclic alpha-amino-gamma-hydroxy-amides, process for their preparation and pharmaceutical compositions thereof | Les Laboratoires Servier (FR) | 2003-01-02 | — | — | EP | disclosed |