Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLAU | P00749 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.39 |
| ▸ | PSEN1 | P49768 | 4/20 | 0.39 |
| ▸ | PSEN2 | P49810 | 4/20 | 0.39 |
| ▸ | APH1B | Q8WW43 | 4/20 | 0.39 |
| ▸ | NCSTN | Q92542 | 4/20 | 0.39 |
| ▸ | APH1A | Q96BI3 | 4/20 | 0.39 |
| ▸ | PSENEN | Q9NZ42 | 4/20 | 0.39 |
| ▸ | ANPEP | P15144 | 2/20 | 0.37 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.37 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.36 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.36 |
| ▸ | CA1 | P00915 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 1/20 | 0.36 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7091599 | 1.00 | PLAU (0.41) | PLAUCYP1A2CYP2A6PSEN1PSEN2 | |
| SCHEMBL7091597 | 1.00 | PLAU (0.41) | PLAUCYP1A2CYP2A6PSEN1PSEN2 | |
| SCHEMBL25369464 | 0.94 | PLAU (0.48) | PLAUCYP2A6ANPEPMTNR1AMTNR1B | |
| SCHEMBL30588972 | 0.94 | PLAU (0.48) | PLAUCYP2A6ANPEPMTNR1AMTNR1B | |
| SCHEMBL5693079 | 0.80 | PLAU (0.60) | PLAUANPEPMTNR1AMTNR1BCA1 | |
| SCHEMBL10389935 | 0.79 | MAPK1 (0.32) | — | |
| SCHEMBL16466258 | 0.79 | MAPK1 (0.32) | — | |
| SCHEMBL6458908 | 0.79 | SHBG (0.33) | — | |
| SCHEMBL14791326 | 0.79 | SHBG (0.33) | — | |
| SCHEMBL6458899 | 0.79 | SHBG (0.33) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1010694-B1 | Spiroimidazoline derivatives and their use as alpha2-adrenergic antagonists and monoamines-reuptake blockers | SERVIER LAB (FR) | 2003-08-06 | — | — | EP | disclosed |
| US-6172097-B1 | Spiro imidazoline compounds | ADIR ET COMPAGNIE (FR) | 2001-01-09 | — | — | US | disclosed |
| EP-1010694-A2 | Spiroimidazoline derivatives and their use as alpha2-adrenergic antagonists and monoamines-reuptake blockers | ADIR ET COMPAGNIE (FR) | 2000-06-21 | — | — | EP | disclosed |